GARCINOLIC ACID; TRANS-(SH) Chemical Properties

Boiling point:

602.6±55.0 °C(Predicted)

Density 

1.055±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 30 mg/ml

form 

A film

pka

5.00±0.19(Predicted)

Safety Information

Hazard Codes 

T,N

Risk Statements 

25-50

Safety Statements 

61

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

GARCINOLIC ACID; TRANS-(SH) Usage And Synthesis

Description

Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora. It inhibits IL-1β-induced microsomal prostaglandin E₂ synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 μM. It has higher antioxidant activity relative to (±)-α-tocopherol in a cell-free assay when used at a concentration of 0.15 mM.

Uses

Garcinoic Acid displays anti-angiogenic activity as well as anti-oxidative activity in animals.

General Description

Natural product derived from plant source.

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