Astragaloside A Chemical Properties

Boiling point:

895.7±65.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml

form 

A crystalline solid

pka

12.91±0.70(Predicted)

InChI

InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24?,25-,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39+,40-,41+/s3

InChIKey

QMNWISYXSJWHRY-APZLXCBQNA-N

SMILES

[C@@]123CC[C@]4(C)[C@]([H])([C@@H](O)C[C@@]4(C)[C@]1([H])C[C@H](O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)[C@@]1([H])C(C)(C)C(O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)CC[C@]21C3)[C@@]1(C)CC[C@@H](C(O)(C)C)O1 |&1:0,3,5,7,10,12,15,17,18,20,21,23,28,35,38,40,42,46,48,52,r|

LogP

0.628 (est)

CAS DataBase Reference

83207-58-3

Safety Information

HS Code 

29389090

Astragaloside A Usage And Synthesis

Uses

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Health effects

As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

Pharmaceutical Applications

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Astragaloside A(83207-58-3)Related Product Information

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