Dichloro-1,2-dithiacyclopentenone Chemical Properties

Melting point:

52-56 °C

Flash point:

200 °C

storage temp. 

2-8°C

form 

Solid

BRN 

1342220

InChI

InChI=1S/C3Cl2OS2/c4-1-2(5)7-8-3(1)6

InChIKey

QGSRKGWCQSATCL-UHFFFAOYSA-N

SMILES

S1C(Cl)=C(Cl)C(=O)S1

EPA Substance Registry System

4,5-Dichloro-1,2-dithiacyclopentenone (1192-52-5)

Safety Information

Hazard Codes 

T

Risk Statements 

25-37/38

Safety Statements 

36/37/39-45

RIDADR 

2811

WGK Germany 

3

RTECS 

JP1290000

HazardClass 

6.1(b)

PackingGroup 

III

Toxicity

mouse,LD50,intravenous,13mg/kg (13mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07423,

Dichloro-1,2-dithiacyclopentenone Usage And Synthesis

Uses

4,5-Dichloro-3H-1,2-dithiol-3-one (Dichloro-1,2-dithiacyclopentenone) is an E. coli FabH inhibitor (IC50: 2.9 μM). 4,5-Dichloro-3H-1,2-dithiol-3-one can be used as a slimicide in the manufacture of food-contact paper and paperboard [1][2].

Purification Methods

Dissolve it in CH2Cl2 (1g in 250ml), filter, wash it twice with H2O, evaporate and distil the residue in vacuo and then recrystallise it from pet ether. IR: max 1650 cm-1. [Boberg Justus Liebigs Ann Chem 679 109 1964, Boberg Justus Liebigs Ann Chem 693 212 1966, Beilstein 19/4 V 72.]

References

[1] Song X, et al. Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor. Chem Pharm Bull (Tokyo). 2014;62(11):1110-8. DOI:10.1248/cpb.c14-00485
[2] Mary S. Wolfe, et al. Chapter. National Toxicology Program. Book. Toxicology and Regulatory Process. 2006. Pages. 32

Dichloro-1,2-dithiacyclopentenone(1192-52-5)Related Product Information

• DL-Limonene
• 1,3-Cyclopentadiene
• Dichloroacetonitrile
• TRANS-1,3-PENTADIENE
• Dicyclopentadiene
• 1,2-PENTADIENE
• 2',4'-Dichloroacetophenone
• Selenium sulfide
• Cyclopentene
• 1,2-Dichloroethane
• METHYLCYCLOPENTADIENE DIMER
• Dichloroacetic acid
• Disulfur dichloride
• CIS-1,2-DICHLOROETHYLENE
• Dichloro-1,2-dithiacyclopentenone