3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Chemical Properties

Melting point:

205 °C (dec.)(lit.)

storage temp. 

Store at -20°C

solubility 

DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml

form 

A crystalline solid

optical activity

[α]22/D +21.5°, c = 2 in 1 N HCl: ethanol, 1:2

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Usage And Synthesis

Description

3,3'',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5''-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (K_is = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 μM.