(-)-[3R,4S]-CHROMANOL 293B
(-)-[3R,4S]-CHROMANOL 293B Basic information
- Product Name:
- (-)-[3R,4S]-CHROMANOL 293B
- Synonyms:
-
- N-[(3R,4S)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYLETHANESULFONAMIDE
- Chromanol 293B [3R,4S]-(-)-
- Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-
- (-)-[3R,4S]-Chromano
- (-)-[3R
- (-)-[3R,4S]-Chromanol 293B
- 4S]-Chromanol 293B
- (-)-Chromanol 293B
- CAS:
- 163163-24-4
- MF:
- C15H20N2O4S
- MW:
- 324.4
- Product Categories:
-
- Potassium channel
- Mol File:
- 163163-24-4.mol
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(-)-[3R,4S]-CHROMANOL 293B Chemical Properties
- Melting point:
- 192 °C
- Boiling point:
- 474.1±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 18 mg/mL
- form
- solid
- pka
- 12.96±0.60(Predicted)
- color
- white
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MSDS
- Language:English Provider:SigmaAldrich
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(-)-[3R,4S]-CHROMANOL 293B Usage And Synthesis
Definition
ChEBI: Chromanol 293B is a 1-benzopyran.
Biological Activity
Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M).
storage
Room temperature
(-)-[3R,4S]-CHROMANOL 293BSupplier
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