Basic information Safety Supplier Related

(-)-[3R,4S]-CHROMANOL 293B

Basic information Safety Supplier Related

(-)-[3R,4S]-CHROMANOL 293B Basic information

Product Name:
(-)-[3R,4S]-CHROMANOL 293B
Synonyms:
  • N-[(3R,4S)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYLETHANESULFONAMIDE
  • (-)-[3R,4S]-CHROMANOL 293B
  • Chromanol 293B [3R,4S]-(-)-
  • Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-
  • (-)-[3R,4S]-Chromano
  • (-)-[3R
  • (-)-[3R,4S]-Chromanol 293B
  • 4S]-Chromanol 293B
CAS:
163163-24-4
MF:
C15H20N2O4S
MW:
324.4
Product Categories:
  • Potassium channel
Mol File:
163163-24-4.mol
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(-)-[3R,4S]-CHROMANOL 293B Chemical Properties

Melting point:
192 °C
Boiling point:
474.1±55.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: 18 mg/mL
form 
solid
pka
12.96±0.60(Predicted)
color 
white
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36/37-7/9
WGK Germany 
3

MSDS

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(-)-[3R,4S]-CHROMANOL 293B Usage And Synthesis

Definition

ChEBI: Chromanol 293B is a 1-benzopyran.

Biological Activity

Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M).

storage

Room temperature

(-)-[3R,4S]-CHROMANOL 293BSupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
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