CHROMANOL 293B
CHROMANOL 293B Basic information
- Product Name:
- CHROMANOL 293B
- Synonyms:
-
- N-[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide
- TRANS-N-[6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYL-ETHANESULFONAMIDE
- CHROMANOL 293B
- 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
- Chromagnol
- Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-, rel-
- Chromanol 293B >=98% (HPLC), powder
- CAS:
- 163163-23-3
- MF:
- C15H20N2O4S
- MW:
- 324.4
- Product Categories:
-
- Potassium channel
- Mol File:
- 163163-23-3.mol
CHROMANOL 293B Chemical Properties
- Boiling point:
- 474.1±55.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 18 mg/mL
- form
- solid
- pka
- 12.96±0.60(Predicted)
- color
- white
CHROMANOL 293B Usage And Synthesis
Description
Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels. It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner. It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.
Uses
Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.
Definition
ChEBI: Chromanol 293B is a 1-benzopyran.
General Description
Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).
Biological Activity
Blocker of the slow delayed rectifier K + current (I Ks ) (IC 50 = 1-10 μ M). Also blocks the CFTR chloride current (I CFTR ) (IC 50 = 19 μ M).
Biochem/physiol Actions
Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
storage
Room temperature
CHROMANOL 293BSupplier
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