4-AMINO-3-FLUOROBENZOIC ACID Chemical Properties

Melting point:

215-218°C

Boiling point:

320.8±27.0 °C(Predicted)

Density 

1.430±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Hot Water

form 

Fine Needles

pka

4.52±0.10(Predicted)

color 

White to Light yellow to Light orange

InChIKey

JSKXHTHMCCDEGD-UHFFFAOYSA-N

CAS DataBase Reference

455-87-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

RTECS 

DG2525000

HazardClass 

IRRITANT

HS Code 

2922498590

4-AMINO-3-FLUOROBENZOIC ACID Usage And Synthesis

Chemical Properties

Fine Needles

Synthesis

In a 1000 mL round-bottomed single-necked flask, 3-fluoro-4-nitrobenzoic acid (30 g, 190 mmol) was dissolved in 300 mL of a solvent mixture of methanol and tetrahydrofuran, and carbon-loaded palladium (2 g) was added as a catalyst. The reaction system was charged with hydrogen and the reaction was stirred at room temperature for 15 hours. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was collected. The filtrate was dried to give a white solid product. The white solid was further dried in an oven to finally obtain 3-fluoro-4-aminobenzoic acid (24.86 g, 98.6% yield).

References

[1] Patent: CN105294567, 2016, A. Location in patent: Paragraph 0033-0036
[2] Tetrahedron, 2018, vol. 74, # 47, p. 6795 - 6803
[3] Journal of the American Chemical Society, 1944, vol. 66, p. 1631
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2697 - 2706

4-AMINO-3-FLUOROBENZOIC ACID(455-87-8)Related Product Information

• 3-Fluoro-4-nitrobenzoic acid
• 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID
• 4-Amino-2,3-difluorobenzoic acid
• 2,5-Difluoro-4-nitrobenzoic acid
• 4-AMINO-3-FLUOROBENZOIC ACID
• 4-Amino-2,5-Difluorobenzoic Acid
• 2-Amino-6-fluorobenzoic acid 97%,2-AMINO-6-FLUOROBENZOIC ACID (6-FLUOROANTHRANILIC ACID),2-Amino-6-fluorobenzoic acid, 98% (6-Fluoroanthranilic acid)
• 5-Amino-2-fluorobenzoic acid 97%
• 4-Amino-2-Fluorobenzoic Acid 2-Fluoro-4-Aminobenzoic Acid
• 2-Amino-5-fluorobenzoic acid
• Methyl 2-amino-5-fluorobenzoate/ 2-Amino-5-fluorobenzoic acid methyl ester
• 3-Amino-4-fluorobenzoic acid hydrochloride 97%
• 2-AMINO-3-FLUOROBENZOIC ACID
• 2-AMINO-4-FLUOROBENZOIC ACID,2-AMINO-4-FLUOROBENZOIC ACID / 4-FLUOROANTHRANILIC ACID,2-Amino-4-Fluorobenzoic Acid 99%
• ETHYL 3-FLUORO-4-NITROBENZOATE
• METHYL 4-AMINO-2,3-DIFLUOROBENZOATE
• 4-AZIDO-2,3,5,6-TETRAFLUOROBENZOIC ACID STP ESTER SODIUM SALT
• 4-AMINO-2,3,5,6-TETRAFLUORO-BENZOIC ACID METHYL ESTER