Potassium di-tert-butyl phosphate Chemical Properties

Melting point:

247-252°C

storage temp. 

2-8°C

form 

Powder

color 

white

InChIKey

ZSWXMOQFFWMZQH-UHFFFAOYSA-M

CAS DataBase Reference

33494-80-3

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

TSCA 

No

HS Code 

2919900090

Potassium di-tert-butyl phosphate Usage And Synthesis

Uses

Di-tert-butylphosphate Potassium Salt is a catalyst used in organic synthesis. Also used in the preparation of HIV attachment inhibitor BMS-663068.

Application

Utilized as an intermediate to prepare N-phosphonooxymethyl prodrugs, which increase bioavailability, and to prepare Nasicon-type phosphates (i.e., KTi₂(PO₄)₃) used in fast ion conductors with low thermal expansion ceramics.appl

Preparation

Potassium di-tert-butyl phosphate synthesis: Di-tert-butyl phosphite (40.36 mmol) was combined with potassium bicarbonate (24.22 mmol) in 35 ml of water. The solution was stirred in an ice bath and potassium permanganate (28.25 mmole) was added in three equal portions over a period of one hour. The reaction was then allowed to continue for another half hour at room temperature. Decolorizing carbon (600 mg) was then incorporated as the reaction was heated to 60 °C for 15 min. The reaction was then vacuum filtered to remove solid magnesium dioxide. The solid was washed several times with water. The filtrate was then combined with one gram of decolorizing carbon and heated at 60°C for another twenty minutes. The solution was filtered again to give a colorless solution, which was then evaporated in vacuo to give the crude potassium di-tert-butyl phosphate salt.

Flammability and Explosibility

Non flammable

Potassium di-tert-butyl phosphate(33494-80-3)Related Product Information

• Tributyl phosphate
• Potassium sorbate
• Potassium Citrate
• Potassium lactate
• Potassium chloride
• Di-tert-butyl dicarbonate
• Dibutyl phosphate
• Potassium iodide
• Potassium Acetate
• Triisobutyl phosphate
• Potassium persulfate
• Trisodium phosphate
• Tylosin phosphate
• Butyl acetate
• Triethyl phosphonoacetate
• phosphate
• Amifostine Thiol Dihydrochloride
• PHOSPHOENOLPYRUVIC ACID MONOPOTASSIUM SALT