Coptisine chloride
Coptisine chloride Basic information
- Product Name:
- Coptisine chloride
- Synonyms:
-
- 2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE
- COPTISINE CHLORIDE
- COPTISINE CHLORIDE(P)
- 7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride
- Coptisine Hcl
- Coptisine Hydrochloride
- COPTISINECHLORIDE(P)(PLEASECALL)
- 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride
- CAS:
- 6020-18-4
- MF:
- C19H14ClNO4
- MW:
- 355.77
- EINECS:
- 611-948-5
- Product Categories:
-
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- chemical reagent
- Amines
- Heterocycles
- Inhibitor
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 6020-18-4.mol
Coptisine chloride Chemical Properties
- Melting point:
- >258°C (dec.)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- color
- Orange to Dark Orange
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
- InChIKey
- LUXPUVKJHVUJAV-UHFFFAOYSA-M
- SMILES
- C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-]
Coptisine chloride Usage And Synthesis
Chemical Properties
Orange Brown Solid
Uses
Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant.
in vivo
Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2].
IC 50
IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki)
Coptisine chlorideSupplier
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Coptisine chloride(6020-18-4)Related Product Information
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