SINOMENINE HYDROCHLORIDE Chemical Properties

Melting point:

231.0 to 235.0 °C

storage temp. 

Inert atmosphere,2-8°C

solubility 

H2O: soluble20mg/mL, clear

form 

powder

color 

white to beige

optical activity

[α]/D -70 to -90°, c = 1 in H2O

Water Solubility 

Soluble to 100 mM in water

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

QD2163000

HS Code 

29334900

SINOMENINE HYDROCHLORIDE Usage And Synthesis

Description

Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.

Chemical Properties

White Solid

Uses

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.

Purification Methods

Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D 20 -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]

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