Palmatine chloride Chemical Properties

Melting point:

205℃

storage temp. 

Hygroscopic, Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly)

form 

Solid

color 

Yellow

InChI

InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

InChIKey

RLQYRXCUPVKSAW-UHFFFAOYSA-M

SMILES

C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-]

Safety Information

Risk Statements 

20/22-36/38

Safety Statements 

24/45

HS Code 

29339900

Palmatine chloride Usage And Synthesis

Description

Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction. The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles.

Description

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC₅₀s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the Apc^Min+/- mouse model of multiple intestinal neoplasia.

Uses

Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.

Uses

antibacterial, antimalarial, uterine contractant

target

Antifection

References

Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975)

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• PALMATINE CHLORIDE HYDRATE