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Palmatine chloride

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Palmatine chloride Basic information

Product Name:
Palmatine chloride
Synonyms:
  • 2,3,9,10-TETRAMETHOXYPROTOBERBERINCHLORIDE
  • BERBERICINE CHLORIDE
  • PALMATINE CHLORIDE
  • PALMATINE HYDROCHLORIDE
  • Palmatine HCL
  • PalMatin hydrochloride
  • 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium chloride
  • (947153-64-2) palmatine chloride
CAS:
10605-02-4
MF:
C21H22ClNO4
MW:
387.86
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
Mol File:
10605-02-4.mol
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Palmatine chloride Chemical Properties

Melting point:
205℃
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
color 
Yellow
InChI
InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1
InChIKey
RLQYRXCUPVKSAW-UHFFFAOYSA-M
SMILES
C12=CC3=C(C(OC)=C(OC)C=C3)C=[N+]1CCC1C=C(OC)C(OC)=CC2=1.[Cl-]
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Safety Information

Risk Statements 
20/22-36/38
Safety Statements 
24/45
HS Code 
29339900
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Palmatine chloride Usage And Synthesis

Description

Corydalis paUida yields this alkaloid which occurs in the quaternary base fraction. The alkaloid is separated by droplet countercurrent chromatography and crystallizes from H20 as yellow-green needles.

Description

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 0.51 and 6.84 μM, respectively). Palmatine (20, 40, and 80 μM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1β, IL-6, and TNF-α levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS; ). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.

Uses

Palmatine Chloride is a protoberberine alkaloid, as a potential anti-inflammatory and anti-hypertensive agent.

Uses

antibacterial, antimalarial, uterine contractant

in vivo

Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells[1].? Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice[2].? Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice[4].? Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice[5].

Animal Model:DSS- induced Colitis BALB/c mice model (8-week-old)[1]
Dosage:50 or 100 mg/kg
Administration:Orally, daily, for 7 days
Result:Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells; remarkably extended the colon length; significantly suppressed the colonic MPO activity. Decreased the levels of colonic inflammatory cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10); Protected mucosal integrity by modulating TJs protein and apoptosis proteins; Restored DSS-induced decreases of TJ protein ZO-1, ZO-2 and claudin-1; Reduced Bax expression and enhanced Bcl-2 expression at the dose of 100?mg/kg, prevented epithelial apoptosis and improved intestinal integrity. Prevented DSS-induced changes of gut microbiota in colitis mice.
Animal Model:Male ICR mice (20–22 g), D-galactosamine/lipopolysaccharide (GalN/LPS)-induced fulminant hepatic failure model[2]
Dosage:25, 50, 100, or 200 mg/kg
Administration:Intraperitoneal injection, 1 h before the GalN/LPS treatment
Result:Attenuated the mortality and serum aminotransferase activities increased by GalN/LPS. Prevented the increase of serum TNF-α and augmented that of serum IL-10. Decreased the TNF-a mRNA expression and increased the IL-10 mRNA expression. Attenuated the apoptosis of hepatocytes.
Animal Model:Swiss young male albino mice, with Scopolamine (HY-N0296)- and diazepam-induced amnesia model[4]
Dosage:0.1, 0.5, 1 mg/kg
Administration:Intraperitoneal injection, 10 days
Result:Significantly improved learning and memory of mice at 0.5 and 1 mg/kg and did not show any significant effect on locomotor activity of the mice. Significantly reversed scopolamine- and diazepam-induced amnesia in mice. Significantly reduced brain acetylcholinesterase activity of mice.
Animal Model:BALB/c-nude mice, HCT-116 xenograft model[5]
Dosage:33.75, 67.5 and 135 mg/kg
Administration:Oral administration, once a day for 26 days
Result:The tumor volume and weight of the treatment group were significantly reduced.

target

Antifection

IC 50

IDO-1: 3 μM (IC50, HEK 293-hIDO-1); IDO-1: 157 μM (IC50, rhIDO-1); WNV NS2B-NS3: 96 μM (IC50)

References

Tani, Nakagura, Hattori, Yakugaku Zasshi, 95, 1103 (1975)

Palmatine chlorideSupplier

Chengdu Chenlv Herb Co., Ltd. Gold
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028-88523492 15528171243
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chenrongpharma@126.com
Shanghai Jiaoze Industrial Co., LTD Gold
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021-37318802 18616909727
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liangpanpan@sh-jiaoze.com
Hubei DAHAO Chemical Co., Ltd. Gold
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027-59106191 13986034860
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1400828855@qq.com
Chembest Research Laboratories Limited
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+86-21-20908456
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sales@BioChemBest.com
Adamas Reagent, Ltd.
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400-6009262 16621234537
Email
chenyj@titansci.com
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