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Berberine hydrochloride

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Berberine hydrochloride Basic information

Product Name:
Berberine hydrochloride
Synonyms:
  • TIMTEC-BB SBB006488
  • NATURAL YELLOW 18 CHLORIDE
  • NATURAL YELLOW 18
  • UMBELLATINE
  • BERBERINE HCL
  • BERBERINE HYDROCHLORIDE
  • BERBERIN HCL
  • BERBERINE HYDROCHLORIDE N-HYDRATE
CAS:
633-65-8
MF:
C20H18ClNO4
MW:
371.81
EINECS:
211-195-9
Product Categories:
  • plant extract
  • Natural Plant Extract
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Plant extracts
  • standardized herbal extract
Mol File:
633-65-8.mol
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Berberine hydrochloride Chemical Properties

Melting point:
204-206 °C (dec.)
storage temp. 
+2C to +8C
solubility 
methanol: soluble
form 
Yellow powder
Colour Index 
75160
color 
Yellow powder
Water Solubility 
SOLUBLE IN COLD WATER
BRN 
3836585
InChIKey
VKJGBAJNNALVAV-UHFFFAOYSA-M
CAS DataBase Reference
633-65-8
EPA Substance Registry System
Berberine chloride (633-65-8)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
24/25-36-26
RIDADR 
1544
WGK Germany 
2
RTECS 
DR9866400
3-10
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29349990
Toxicity
LD50 orl-rat: >15 g/kg KSRNAM 8,654,74

MSDS

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Berberine hydrochloride Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant

Uses

An isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells. Al so inhibits Activator Protein 1 (AP-1), a transcription factor that plays a critical role in inflammation and carcinogenesis. Treatment with berberine potentially results in the reduced accumulation o f chemotherapeutic drugs.

Uses

An ingredient in some commercial eyewash products.

Safety Profile

Poison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

Purification Methods

Berberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]

Berberine hydrochlorideSupplier

Shaanxi Pioneer Biotech CO., Ltd Gold
Tel
029-86107037-8019
Email
jeff@pioneer-biotech.com
Shanghai ChengShao Biological Technology Co., Ltd. Gold
Tel
021-61847300 13341622919
Email
shcss01@163.com
Shanghai Zheyuan Chemical Co., Ltd. Gold
Email
my_furongdi@163.com
Shaanxi Kondopu Biotechnology Co. LTD Gold
Tel
184-2900-1220
Email
1140835348@qq.com
Tianmen Hengchang Chemical Co., Ltd Gold
Tel
027-59322316- ;027-59322316-
Email
1208480077@qq.com;1178380066@qq.com