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STACHYDRINE HYDROCHLORIDE

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STACHYDRINE HYDROCHLORIDE Basic information

Product Name:
STACHYDRINE HYDROCHLORIDE
Synonyms:
  • STACHYDRINE HYDROCHLORIDE
  • (S)-2-carboxy-1,1-dimethylpyrrolidinium chloride
  • StachydrineHCl
  • Stachydrine hydrichloride
  • 2-Carboxy-1,1-dimethylpyrrolidinium chloride
  • Stachydrine chloride
  • Stachydrine hydrochlori
  • Stachydrine chloride 2-Carboxy-1,1-dimethylpyrrolidinium chloride
CAS:
4136-37-2
MF:
C7H14ClNO2
MW:
179.64
EINECS:
223-957-8
Product Categories:
  • Ammonium Chlorides (Quaternary)
  • Quaternary Ammonium Compounds
Mol File:
4136-37-2.mol
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STACHYDRINE HYDROCHLORIDE Chemical Properties

Melting point:
225°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water
Merck 
14,8771
Stability:
Hygroscopic
CAS DataBase Reference
4136-37-2(CAS DataBase Reference)
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Safety Information

Risk Statements 
20-22
Safety Statements 
22-45-36/37/39
HS Code 
29339900
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STACHYDRINE HYDROCHLORIDE Usage And Synthesis

Uses

Stachydrine Chloride is a constituent of the Chinese herb leonurus heterophyllus sweet. its used in clinics to support blood circulation and dispel blood stasis.

Biological Activity

stachydrine is an anti-metastatic agent.stachydrine, a pyrrolidine betaine, was first isolated from seed husk and the pulp of the fruit of c. leonurus, and many other asian plants and fruits.

in vitro

the aim of a previous study was to investigate the effects of stachydrine (sta) on norepinephrine (ne) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes. results showed that ne treatment could increase protein synthesis, cell surface area, the expression level of β-mhc and β/α-mhc ratio and these effects were attenuated by sta treatment. in addition, ne-induced hypertrophy was associated with accelerated decay of ca2+-transient, increased phospholamban expression, increased ca2+-transient amplitude, hyper-phosphorylation, increased intracellular camp level, as well as pka overactivation. all of these effects could be inhibited by sta treatment significantly [1].

in vivo

previous study evaluated the effect of stachydrine on the expression of caspase-9 and 12 in rats with unilateral ureteral obstruction. results showed that degree of renal interstitial fibrosis, serum creatinine, blood urea nitrogen, the renal tubular interstitial damage index, and expression of caspase-9 and 12 in the stachydrine-treatment groups were significantly decreased [2].

target

IL Receptor | T-bet | RORγt | GATA-3 | Foxp3

References

[1] zhang, c. ,shan, x.-l.,liao, y.-l., et al. effects of stachydrine on norepinephrine-induced neonatal rat cardiac myocytes hypertrophy and intracellular calcium transients. bmc complement. altern. med. 14, 474 (2014).
[2] zhang c, lu y, zhou yj, tong qq, qu c, kang tj. the effect of stachydrine on the expression of caspase-12 in rats with unilateral ureteral obstruction. j urol. 2014 nov;192(5):1549-54.

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