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Corydaline

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Corydaline Basic information

Product Name:
Corydaline
Synonyms:
  • [7S,13S,13aR,(+)]-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-13-methyl-6H-dibenzo[a,g]quinolizine
  • d-Corydaline
  • 2,3,9,10-TetraMethoxy-13-Methylberbine, 8CI
  • Corydalis A
  • (13s-e)-thyl
  • 2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin
  • 2,3,9,10-tetramethoxy-13-methyl-berbin
  • 6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me
CAS:
518-69-4
MF:
C22H27NO4
MW:
369.45
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
Mol File:
518-69-4.mol
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Corydaline Chemical Properties

Melting point:
135°
alpha 
D20 +311° (c = 0.8 in alc)
Boiling point:
499.57°C (rough estimate)
Density 
1.1771 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
2-8°C(protect from light)
solubility 
Chloroform (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
6.57±0.40(Predicted)
color 
White to Off-White
InChI
InChI=1S/C22H27NO4/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23/h6-7,10-11,13,21H,8-9,12H2,1-5H3/t13-,21+/m0/s1
InChIKey
VRSRXLJTYQVOHC-YEJXKQKISA-N
SMILES
C12=CC(OC)=C(OC)C=C1CCN1[C@]2([H])[C@@H](C)C2=CC=C(OC)C(OC)=C2C1
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Safety Information

HS Code 
2939799090
Toxicity
LD50 in mice (mg/kg): 135.5 ± 12.8 i.v. (Anderson, Chen)
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Corydaline Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the tubers of Yanhuoso, the whole grass of Xiaoquan Ziziphus, the roots of Shamanshan Ziziphus, the tubers and above-ground parts of Malcha Ziziphus.

Uses

Corydaline is a common herbal drug used in Chinese medicine and is touted as an analgesic with reported anti-angiogenic effects.

Definition

ChEBI: Corydaline is an isoquinoline alkaloid and a member of isoquinolines.

in vivo

Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior[3].

Animal Model:Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid[3]
Dosage:10 mg/kg
Administration:Subcutaneous administration; once
Result:Showed antinociceptive effects in mice.

IC 50

AChE; μ Opioid Receptor/MOR

CorydalineSupplier

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