N-Boc-2-piperidone Chemical Properties

Melting point:

29-36 °C

Boiling point:

110°C/0.1mmHg(lit.)

Density 

1.099±0.06 g/cm3(Predicted)

Flash point:

>110 °C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol

form 

Solid

pka

-2.29±0.20(Predicted)

color 

Off-White

BRN 

4674955

InChI

InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-7-5-4-6-8(11)12/h4-7H2,1-3H3

InChIKey

ULMHMJAEGZPQRY-UHFFFAOYSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCCCC1=O

CAS DataBase Reference

85908-96-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

N

Risk Statements 

50

Safety Statements 

24/25-61

RIDADR 

UN 3082

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29337900

MSDS

• Language:English Provider:ALFA

N-Boc-2-piperidone Usage And Synthesis

Chemical Properties

Off-White Low Melting Solid

Uses

N-Boc-2-piperidone(85908-96-9) is used as a synthetic intermediate in the preparation of various biological inhibitors.

Preparation

4-Benzensulfonylmethyl-4-hydroxy-piperidine TFA (B-1) Diisopropylethylamine (28.3 mL, 162.75 mmol) and di-t-butyl dicarbonate (28.4 g, 130.02 mmol) were added in sequence to a mixture of piperidone hydrate hydrochloride (12) (10.0 g, 65.1 mmol) in methanol (50 mL).  The mixture was stirred at room temperature for 20 hours. After that, removed the solvent  and the remaining was separated with ether and 1 M KHSO₄ solution.  The organic layer was washed with brine and saturated NaHCO₃.  Finally, N-Boc-2-piperidone was obtained after purification.

Definition

ChEBI:N-Boc-2-piperidone-protected by t-Boc. It is also known as 1-N-Boc-2-piperidone,1-N-Boc-2-piperidone, or 1-(tert-Butoxycarbonyl)-2-piperidone. 

N-Boc-2-piperidone(85908-96-9)Related Product Information

• 2,2,6,6-Tetramethyl-4-piperidinol
• DROPERIDOL
• Haloperidol
• 2-Piperidone
• 4,4-Piperidinediol hydrochloride
• DI-TERT-BUTYL ETHER
• 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate
• (R)-1-Boc-4-piperidone-2-carboxylic acid, 98+%
• N-(tert-Butoxycarbonyl)-4-piperidone
• Ethyl-N-Boc-4-piperidone-3-carboxylate
• 1-Boc-3-piperidone,97%,BOC-3-PIPERIDONE,N-Boc-3-piperidone,1-BOC-3-PIPERIDONE,1-N-BOC-3-PIPERIDONE
• Diphenoxylate
• TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE
• N-Boc-2-piperidone
• Methyl N-Boc-4-piperidone-2-carboxylate
• TERT-N-BOC-4-PIPERIDONE
• 2-tert-Butyl 6-methyl 4-bromo-3-oxo-2-azabicyclo[3.1.0]hex-3-ene-2,6-dicarboxylate
• (S)-6-OXO-PIPERIDINE-1,2-DICARBOXYLIC ACID 2-BENZYL ESTER 1-TERT-BUTYL ESTER