Saikosaponin a
Saikosaponin a Basic information
- Product Name:
- Saikosaponin a
- Synonyms:
-
- SAIKOSAPONIN A(RG)
- Thesaikosaponin A
- SAIKOSAPONIN A
- dihydroxyolean-11-en-3-yl6-deoxy-3-O-β-D-
- β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23-
- [(3β,4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
- [(4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
- SABINYL ACETATE(RG)
- CAS:
- 20736-09-8
- MF:
- C42H68O13
- MW:
- 780.98
- EINECS:
- 633-799-5
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Saponins
- Mol File:
- 20736-09-8.mol
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Saikosaponin a Chemical Properties
- Melting point:
- 225～232℃ (dec.)
- Boiling point:
- 893.7±65.0 °C(Predicted)
- Density
- 1.163～1.168 g/ml
- refractive index
- 1.571～1.574 (20/D)
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly)
- pka
- 12.83±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChIKey
- KYWSCMDFVARMPN-FMIBPMOUSA-N
- CAS DataBase Reference
- 20736-09-8
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Safety Information
- Safety Statements
- 24/25
- HS Code
- 29389090
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Saikosaponin a Usage And Synthesis
Chemical Properties
Pale yellow crystals, easily soluble in water and dilute alcohol, difficult to dissolve in benzene, ether and chloroform, derived from the aerial parts of Bupleurum chinense.
Uses
Saikosaponin A was shown to exhibit anti-inflammatory activities by suppressing activation of NF-kB signaling pathway.
Definition
ChEBI: Saikosaponin A is a saikosaponin.
in vivo
Saikosaponin A (1-10 mg/kg, i.p, 7 d) attenuates the morphological changes in the small intestine induced by 5-FU[2].
Saikosaponin-A (1-10 mg/kg, i.p, 7 d) enhances the decrease of antioxidant enzymes in intestinal tissue caused by 5-FU[2].
| Animal Model: | 5-FU (HY-90006)-induced mucositis in BALB/c mice modle[2] |
| Dosage: | 1, 5, 10?mg/kg/day, 7 d |
| Administration: | injected intraperitoneally (i.p) |
| Result: | Reduced villus blunting, crypt cells apoptosis, and inflammatory cell infiltration. Decreased concentration of GSH, GST, Catalase, and SOD in intestinal tissue. |
Saikosaponin aSupplier
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