Ginsenoside Rh2
Ginsenoside Rh2 Basic information
- Product Name:
- Ginsenoside Rh2
- Synonyms:
-
- b-D-Glucopyranoside, (3b,12b)-12,20-dihydroxydaMMar-24-en-3-yl
- (3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside
- Ginsenoside Rh2, 20(S)-
- (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl beta-d-glucopyranoside
- GINSENOSIDE RH2
- dihydroxydammar-24-en-3-yl
- β-D-Glucopyranoside, (3β,12β)-12,20-
- R-form-Ginsenoside Rh2
- CAS:
- 78214-33-2
- MF:
- C36H62O8
- MW:
- 622.88
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Inhibitors
- Ginsenoside series
- 78214-33-2
- Mol File:
- 78214-33-2.mol
Ginsenoside Rh2 Chemical Properties
- Melting point:
- 139-144 °C
- Boiling point:
- 726.4±60.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- pka
- 12.91±0.70(Predicted)
- color
- White
- InChIKey
- CKUVNOCSBYYHIS-IRFFNABBSA-N
- LogP
- 5.620 (est)
- CAS DataBase Reference
- 78214-33-2(CAS DataBase Reference)
Ginsenoside Rh2 Usage And Synthesis
Description
Ginsenoside Rh2 is a steroid glycoside found in plants of the genus Panax that has diverse biological activities. It inhibits release of β-hexosaminidase from RBL-2H3 cells (IC50 = 100 μM) and inhibits the IgE-dependent passive cutaneous anaphylaxis reaction in mice at a dose of 25 mg/kg. It inhibits growth of HRA ovarian and BxPC-3 pancreatic cancer cells in a dose-dependent manner. In vivo, ginsenoside Rh2 decreases immobility time in the forced swim test in a mouse model of colorectal carcinoma. Ginsenoside Rh2 also reduces infarct volume in a rat model of ischemia-reperfusion-induced brain injury.
Chemical Properties
White solid
Uses
20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro.
Definition
ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.
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