Basic information Safety Supplier Related

Ginsenoside-Rg5

Basic information Safety Supplier Related

Ginsenoside-Rg5 Basic information

Product Name:
Ginsenoside-Rg5
Synonyms:
  • Ginsenoside-Rg5
  • (3beta,12beta,20E)-12-Hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
  • Ginsenoside Rg5, 98%, from Panax ginseng C. A. Mey.
  • Ginsenoside Rg5, >99%
  • b-D-Glucopyranoside, (3b,12b,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-b-D-glucopyranosyl-
  • β-D-Glucopyranoside, (3β,12β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-β-D-glucopyranosyl-
  • (8ξ,9ξ,12α,13ξ,14β,17β)-12-Hydroxy-4,4,7,10,14-pentamethyl-17-[(2 E)-6-methyl-2,5-heptadien-2-yl]gonan-3-yl 2-O-β-D-glucopyranosyl- β-D-glucopyranoside
  • GinsenosideRrg5
CAS:
186763-78-0
MF:
C42H70O12
MW:
767
Mol File:
186763-78-0.mol
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Ginsenoside-Rg5 Chemical Properties

Boiling point:
855.6±65.0 °C(Predicted)
Density 
1.28±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
Soluble in DMSO; sparingly soluble in methanol;
form 
powder
pka
12.85±0.70(Predicted)
color 
White
Water Solubility 
insoluble in water
InChIKey
NJUXRKMKOFXMRX-SELNEYDKSA-N
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Ginsenoside-Rg5 Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng.

Uses

Ginsenoside Rg5 is an aromatase inhibitor from Panax ginseng leaves. Also, it ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of inflammation, oxidative stress, and apoptosis.

Definition

ChEBI: A natural product found in Panax japonicus var. major.

in vivo

Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues[2].

target

TNF-α | IL Receptor | AChR | COX | NOS | Beta Amyloid | ERK | FAK | Akt | MMP(e.g.TIMP) | NF-kB | AP-1 | ROS | HO-1 | TLR | CDK | p21

IC 50

IGF-1R: 90 nM (IC50); p65; COX-2

Ginsenoside-Rg5Supplier

cjbscvictory Gold
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13348960310
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3003867561@qq.com
Adamas Reagent, Ltd.
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400-6009262 16621234537
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chenyj@titansci.com
ShangHai YuanYe Biotechnology Co., Ltd.
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021-61312847 13636370518
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shyysw007@163.com
Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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cwb1@biopurify.cn
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Email
winherb@126.com
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Ginsenoside-Rg5(186763-78-0)Related Product Information