Ginsenoside Rk3
Ginsenoside Rk3 Basic information
- Product Name:
- Ginsenoside Rk3
- Synonyms:
-
- Ginsenoside Rk3
- Ginsenoside Rk3 standard
- β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl
- Ginsenoside Rk3, 10 mM in DMSO
- CAS:
- 364779-15-7
- MF:
- C36H60O8
- MW:
- 620.87
- Mol File:
- 364779-15-7.mol
Ginsenoside Rk3 Chemical Properties
- Boiling point:
- 722.4±60.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 12.91±0.70(Predicted)
- color
- White to off-white
Ginsenoside Rk3 Usage And Synthesis
Uses
Ginsenoside Rk3 is isolated from the root of Panax notoginseng which exhibits high inhibitory activity against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes.
in vivo
The inhibitory effects of Ginsenoside Rk3 (Rk3) on tumor progression are studied in vivo using a H460 xenograft model in nude mice. Compared with the control group, a significant inhibition of tumor growth (volume) is observed in the Ginsenoside Rk3-treated group. Twenty-one days after treatment initiation, tumor growth is significantly inhibited by approximately 62.99% in the mice receiving 20 mg/kg Ginsenoside Rk3, similar to the inhibitory effect observed in the 20 mg/kg Gefitinib-treated group (57.21%). Compared with the control group, tumor growth is moderately inhibited in the mice receiving 10 and 5 mg/kg Ginsenoside Rk3, with inhibition rates of 32.54% and 11.84%, respectively[2].
IC 50
NF-κB: 14.24 μM (IC50, in HepG2 cells); NF-κB: 15.32 μM (IC50, in SK-Hep1 cell)
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