Ginsenoside Rd Chemical Properties

Melting point:

204～206℃

Boiling point:

1015.6±65.0 °C(Predicted)

Density 

1.38±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

12.85±0.70(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

InChIKey

FBFMBWCLBGQEBU-FIKSETHBNA-N

LogP

3.110 (est)

CAS DataBase Reference

52705-93-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

2-45

WGK Germany 

3

HS Code 

29389090

Ginsenoside Rd Usage And Synthesis

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rd is a protopanaxadiol which is more abundant in some Panax species (e.g., P. quinquefolium) than others. This ginsenoside has diverse in vitro and in vivo effects, including cardioprotective, neuroprotective, and anti-inflammatory actions. Notably, ginsenoside Rd is converted to other ginsenosides in response to steaming or heating plant materials, leading to loss of these activities.

Chemical Properties

White to off-white crystals powder

Uses

Ginsenoside RD has been shown to attenuate tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after forebrain ischemia. This could be used to counter the risk of developing post-stroke dementia.

Definition

ChEBI: Ginsenoside Rd is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is (20S)-ginsenoside Rg3 in which the hydroxy group at position 20 has been converted to its beta-D-glucopyranoside. It has a role as a vulnerary, a neuroprotective agent, an apoptosis inducer, an anti-inflammatory drug, an immunosuppressive agent and a plant metabolite. It is a ginsenoside, a beta-D-glucoside and a tetracyclic triterpenoid. It is functionally related to a (20S)-ginsenoside Rg3.

in vivo

IC 50

NF-κB: 12.05 μM (IC₅₀, in HepG2 cells); COX-2; L-type calcium channel; CYP2D6: 58 μM (IC₅₀); CYP1A2: 78.4 μM (IC₅₀); CYP3A4: 81.7 μM (IC₅₀); CYP2C9: 85.1 μM (IC₅₀)

References

[1] CHIEH-FU CHEN  Jun tian Z  Wen fei Chiou. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium[J]. Acta Pharmacologica Sinica, 2008, 29 9: 1103-1108. DOI: 10.1111/j.1745-7254.2008.00868.x
[2] YANG WANG. Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3β signaling and inhibition of the mitochondria-dependent apoptotic pathway.[J]. PLoS ONE, 2013: e70956. DOI: 10.1371/journal.pone.0070956
[3] X. LIU. Ginsenoside-Rd improves outcome of acute ischaemic stroke – a randomized, double-blind, placebo-controlled, multicenter trial[J]. European Journal of Neurology, 2012, 19 6: 855-863. DOI: 10.1111/j.1468-1331.2011.03634.x
[4] SEOK BEAN SONG. Inhibition of TNF-α-mediated NF-κB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves.[J]. Journal of Ginseng Research, 2012, 36 2: 146-152. DOI: 10.5142/jgr.2012.36.2.146

Ginsenoside Rd(52705-93-8)Related Product Information

• Ginsenoside Rh2
• Ginsenoside Re
• Ginsenoside Rg1
• Ginsenoside Rb1
• Ginseng extract
• 20(R)-Ginsenoside Rg3
• TRIBULOSIDE
• GINSENOSIDE RE
• Ginsenoside Rh1
• Ginsenoside Rf
• GINSENOSIDEF1
• Ginsenoside-Rg5
• Ginsenoside Rb3
• Ginsenoside Rk3
• Ginsenoside Rg2
• GINSENOSIDE RB2
• GinsenosideRo
• Ginsenoside Rc