GINSENOSIDE F2 Chemical Properties

Melting point:

195-200°C

Boiling point:

871.5±65.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

12.91±0.70(Predicted)

form 

Solid

color 

White to Off-White

Stability:

Hygroscopic

GINSENOSIDE F2 Usage And Synthesis

Description

Ginsenoside F₂ is a ginsenoside that has been found in P. ginseng and has diverse biological activities. It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM. Ginsenoside F₂ (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC₅₀ = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day. Ginsenoside F₂ (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; ) in mice. It is a human intestinal bacterial metabolite of ginsenoside Rb₁ via the intermediate ginsenoside Rd .

Uses

Ginsenoside F2 is a bioactive metabolite of the ginsenoside component of Panax ginseng with the ability to regulate element-binding protein cleavage activating protein and transforming growth factor-β pathways. This control over apoptosis can lead to a control over hair growth and hair loss in mammals.

Definition

ChEBI: A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosides, and in which a double bond has been introduced at the 24-25 position.

GINSENOSIDE F2(62025-49-4)Related Product Information

• Ginsenoside Rc
• Ginsengrootextract
• 20(R)-Ginsenoside Rg3
• Ginsenoside Rb1
• Ginsenoside Rh2
• Ginsenoside Rb3
• GINSENOSIDE F3
• (R) -ginsenoside Rh1
• Panaxadiol
• Panaxatriol
• GINSENOSIDEF1
• GinsenosideRo
• Ginsenoside Rh1
• Pseudoginsenoside RT5
• Ginsenoside RK2
• Ginsenoside Rg2
• Ginsenoside Re
• Ginsenoside Rf