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Ginsenoside Ra3

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Ginsenoside Ra3 Basic information

Product Name:
Ginsenoside Ra3
Synonyms:
  • Ginsenoside Ra3
  • (3beta,12beta)-12-Hydroxy-20-[(O-beta-D-xylopyranosyl-(1-3)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl)oxy]dammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
  • β-D-Glucopyranoside, (3β,12β)-12-hydroxy-20-[(O-β-D-xylopyranosyl-(1→3)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)oxy]dammar-24-en-3-yl 2-O-β-D-glucopyranosyl-
  • Ginsenoside Ra3 USP/EP/BP
  • (20S)-protopanaxadiol 3-O-(β-D-glucopyranosyl(1<*>2)-β-D-glucopyranosido)-20-O-β-D-xylopyranosyl(1<*>3)-β-D-glucopyranosyl(1<*>6)-β-D-glucopyranoside
  • Ginsenoside Ra3,Ginsenoside Ra-3,Inhibitor,inhibit,Ginsenoside Ra 3
  • Ginsenoside Ra3, 10 mM in DMSO
CAS:
90985-77-6
MF:
C59H100O27
MW:
1241.42
Mol File:
90985-77-6.mol
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Ginsenoside Ra3 Chemical Properties

Density 
1.48±0.1 g/cm3(Predicted)
pka
12.69±0.70(Predicted)
form 
Solid
color 
White to off-white
InChIKey
QUNSGRLNZDSQJC-UHFFFAOYSA-N
SMILES
CC12CCC3C(C(OC4OC(CO)C(O)C(O)C4OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C1CC(O)C1C(C(C)(CCC=C(C)C)OC3C(C(O)C(O)C(COC4OC(CO)C(O)C(OC5OCC(O)C(O)C5O)C4O)O3)O)CCC21C)(C)C
CAS DataBase Reference
90985-77-6
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Ginsenoside Ra3 Usage And Synthesis

Uses

Ginsenoside Ra3 is a chemical constituent from the root and rhizomes of panax ginseng. Ginsenoside Ra3 is one of the ginsenosides, which are considered the major active medicinal components of ginsengs.

Synthesis

Ginsenoside Ra3 is isolated and purified from red ginseng. Steps: 1) Red ginseng is extracted with 75% ethanol under hot reflux to give the total extract. 2) The total extract is dissolved in 5% ethanol and loaded onto a D101 macroporous resin column. Elution with 25% and then 75% ethanol is performed. The 75% eluate is collected to yield total saponins. 3) Total saponins are dissolved in 5% methanol and loaded onto an MCIGELCHP20 microporous resin column. Stepwise elution with methanol containing formic acid at different concentrations is used. Specific fractions are collected to obtain the target ginsenoside A segment. 4) Segment A is separated by high-speed counter-current chromatography using a specific solvent system. The effluent corresponding to the ginsenoside Ra3 chromatographic peak is collected based on the chromatogram, then concentrated and dried.

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