Ginsenoside Rg3 Chemical Properties

Melting point:

315-318°C

Boiling point:

885.0±65.0 °C(Predicted)

Density 

1.30

storage temp. 

2-8°C

solubility 

DMSO: ≥5mg/mL

pka

12.85±0.70(Predicted)

form 

powder

color 

white to beige

optical activity

[α]/D +10 to +20°, c = 1 in methanol

InChIKey

RWXIFXNRCLMQCD-JBVRGBGGSA-N

CAS DataBase Reference

14197-60-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

RTECS 

LY9537300

HS Code 

29389090

Toxicity

mouse,LD50,intraperitoneal,1250mg/kg (1250mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.

Ginsenoside Rg3 Usage And Synthesis

Description

Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax. Structurally, they are steroid glycosides derived from the triterpene squalene. Ginsenoside Rg₃ is a panaxadiol found in white and red P. ginseng. This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions. Ginsenoside Rg₃ induces apoptosis and inhibits angiogenesis in a variety of cancer models. Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.

Uses

Ginsenoside Rg3 has been used to investigate its modulatory effects on delayed rectifier potassium current (IKr) channels in long QT syndrome (LQTS)2-human induced pluripotent stem cells (hiPSC-CMs).

Uses

Ginsenoside Rg3 shows a synergistic antitumor effect with cisplatin in cisplatin-resistant bladder tumor cell lines and is considered to be an anti-tumor agent.

Definition

ChEBI: (20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.

Biochem/physiol Actions

Ginsenoside Rg3 is a natural product isolated from Panax ginseng. Similar to other ginsenosides it exhibits cardio protective effects. Ginsenoside Rg3 enhances cardiac, hERG (IKr) and KCNQ (Iks), channel currents by interaction with the channel pore entryway. It also inhibits the palmitate-induced apoptosis of MIN6N8 mouse insulinoma beta-cells through modulating p44/42 MAPK activation. Ginsenoside Rg3 increases the level of the transcription factor Nrf2 and induces the mRNA levels of multidrug resistance-associated protein (Mrp) 1 and Mrp3. Rg3 modulate neuroinflammation by attenuating the activation of microglia in response to systemic LPS treatment. It activates AMPK in HepG2 cells and reduces the lipid accumulation thereby decreasing the risk of cardiovascular disease due to dyslipidemia.

Ginsenoside Rg3(14197-60-5)Related Product Information

• ginsenoside Rh(4)
• GINSENOSIDE RB2
• Ginsenoside Rc
• Ginsenoside Rb1
• Ginseng extract
• GinsenosideRo
• Ginsenoside Rg2
• PANAX NOTOGINSENOSIDES
• Ginsenoside Re
• Ginsenoside Rh2
• Escin
• Ginsenoside Rg1
• GINSENOSIDE RE
• TRIBULOSIDE
• Ginsenoside Rd
• Ginsenoside Rf
• Ginsenoside CK
• 20(R)-Ginsenoside Rg3