L-Canavanine sulfate
L-Canavanine sulfate Basic information
- Product Name:
- L-Canavanine sulfate
- Synonyms:
-
- canavanine sulphate
- L-canavanine sulfate crystalline
- L-Canavanine Sulfate, Canavalia ensiformis
- l-α-amino-γ-(guanidinooxy)butyric acid sulfate salt
- CANAVANINE SULFATE, L-(RG)
- L-CANAVANINE SULFATE HYDRATE
- L-CANAVANINE SULFATE
- CANAVANINE SULFATE
- CAS:
- 2219-31-0
- MF:
- C5H14N4O7S
- MW:
- 274.25
- EINECS:
- 218-728-4
- Product Categories:
-
- amino acid derivative
- Amino Acids & Derivatives
- Hydroxylamines (N-Substituted)
- Amino Acids
- Inhibitors
- Nitric Oxide Reagents
- Amino Acids
- Biochemistry
- Hydroxylamines
- Hydroxylamines (O-Substituted)
- non-Proteinorganic Amino Acids
- chem-chemical
- Mol File:
- 2219-31-0.mol
L-Canavanine sulfate Chemical Properties
- Melting point:
- 160-165 °C (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- color
- white
- BRN
- 6121291
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 2219-31-0(CAS DataBase Reference)
- EPA Substance Registry System
- L-Canavanine sulfate (2219-31-0)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 36-26
- RIDADR
- 2811
- WGK Germany
- 3
- HS Code
- 2925290090
MSDS
- Language:English Provider:SigmaAldrich
L-Canavanine sulfate Usage And Synthesis
Uses
A Nitric Oxide Synthase inhibitor
Uses
Canavanine sulfate salt has been used:
- as a translation inhibitor in yeast translation studies
- as a component of synthetic complete (SC) drop-out medium for screening yeast
- for screening Saccharomyces cerevisiae in canavanine mutation frequency assay
Definition
ChEBI: An organic sulfate salt obtained by combining L-canavanine with one molar equivalent of sulfuric acid.
General Description
Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.
Biological Activity
NO synthase inhibitor.
Biochem/physiol Actions
Canavanine is a naturally occurring?L-amino acid that competes and interferes with?L-arginine-utilizing enzymes due to its structural similarity with this?L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.
Purification Methods
Recrystallise the sulfate by dissolving (~1g) in H2O (10mL), and adding with stirring 0.5 to 1.0 volumes of 95% EtOH whereby crystals separate. These are collected, washed with Me2CO/EtOH (1:1) and dried over P2O5 in a vacuum. [Hunt & Thompson Biochemical Preparations 13 416 1971, Feacon & Bell Biochem J 59 221 1955, Beilstein 4 III 1636, 4 IV 3188.]
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L-Canavanine sulfate(2219-31-0)Related Product Information
- AMT HYDROCHLORIDE
- 1,4-PBIT DIHYDROBROMIDE
- L-Canavanine sulfate
- L-CANALINE BASE
- Ammonium sulfite monohydrate
- DL-Homoserine
- Ammonium sulfate
- Sulfuric acid
- Formamidine acetate
- L-Canavanine
- Ammonium Sulfite
- Guanidine acetate
- METHYLAMINE SULFATE
- L-HOMOSERINE HYDROCHLORIDE
- L-(+)-CANAVANINE SULFATE MONOHYDRATE 9&,L-(+)-Canavanine sulfate salt monohydrate,L-(+)-CANAVANINE SULFATE MONOHYDRATE, 98 %
- D-Canavanine sulfate
- DL-Canavanine sulfate
- L-(+)-CANAVANINE SULFATE MONOHYDRATE