6-Iodoquinoline Chemical Properties

Melting point:

91°C

Boiling point:

120 °C(Press: 1 Torr)

Density 

1.7856 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

4.23±0.10(Predicted)

color 

White to Light yellow to Light orange

InChIKey

WKTASELJZCIVBR-UHFFFAOYSA-N

CAS DataBase Reference

13327-31-6

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41

Safety Statements 

26-24/25

WGK Germany 

3

HS Code 

29334900

6-Iodoquinoline Usage And Synthesis

Uses

Reactant for:

• Room temperature CuI-catalyzed N-arylation using 2-pyridinyl β-ketones ligands

Synthesis

General procedure for the synthesis of 6-iodoquinoline from 6-bromoquinoline: sodium iodide (4.32 g, 28.8 mmol), copper(I) iodide (137 mg, 0.72 mmol), N,N'-dimethyl-cyclohexane-1,2-diamine (0.227 mL, 1.44 mmol) and 6-bromoquinoline (3 g, 14.4 mmol) in a solution of dioxane (15 mL). The reaction tube was flushed with nitrogen and sealed with a PTFE septum. Nitrogen was bubbled into the solution through a needle for 10 min to ensure that gas escaped through the needle. After removing the needle, the reaction mixture was stirred at 110°C for 15 hours. Upon completion of the reaction, the green suspension was cooled to room temperature, poured into ice water and extracted with dichloromethane. The organic layer was collected, dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography, eluting sequentially with 100% dichloromethane and dichloromethane/methanol (95:5, v/v) to afford 3.56 g (97% yield) of 6-iodoquinoline as a light yellow solid.1H-NMR (DMSO-d6) δ: 8.93 (1H, dd, J = 1.5, 4.1 Hz), 8.47 (1H, d, J = 2.0 Hz ), 8.33 (1H, d, J = 8.6 Hz), 8.02 (1H, dd, J = 2.0, 8.6 Hz), 7.80 (1H, d, J = 8.6 Hz), 7.56 (1H, dd, J = 4.1, 8.6 Hz).

References

[1] Patent: WO2007/75567, 2007, A1. Location in patent: Page/Page column 117-118
[2] Patent: WO2011/18454, 2011, A1. Location in patent: Page/Page column 63-64
[3] Patent: WO2011/20861, 2011, A1. Location in patent: Page/Page column 69
[4] Patent: WO2008/155378, 2008, A1. Location in patent: Page/Page column 70-71
[5] Patent: CN104250257, 2017, B. Location in patent: Paragraph 0258-0260

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