ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Borane > (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Basic information
- Product Name:
- (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
- Synonyms:
-
- ALPHA,ALPHA-DIPHENYL-D-PROLINOL METHYLBORONIC ACID CYCL-AMIDE-ESTER
- (R)-(+)-2-METHYL-CBS-OXAZABOROLIDINE
- (R)-Methyloxazaborolidine,1-1.5Mintoluene[(R)-MeCBS]CoreyCatalyst
- (r)-(+)-2-methyl-cbs-oxazaborolidine solution
- (r)-2-methyl-cbs-oxazaborolidine, 1m soln. in toluene
- α,α-diphenyl-d-prolinol methylboronic acid cycl-amide-ester
- α,α-diphenyl-d-prolinolmethylboronic acid cyclamide ester
- (R)-(+)-Methyl-CBS-oxazaborolidine
- CAS:
- 112022-83-0
- MF:
- C18H20BNO
- MW:
- 277.17
- EINECS:
- 000-000-0
- Product Categories:
-
- Asymmetric Synthesis
- Chiral Catalysts, Ligands, and Reagents
- Asymmetric Synthesis
- B (Classes of Boron Compounds)
- B-Bromocatecholborane, etc.
- Reduction
- Synthetic Organic Chemistry
- organic or inorganic borate
- Mol File:
- 112022-83-0.mol
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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Chemical Properties
- Melting point:
- 85-95 °C(lit.)
- Boiling point:
- 111 °C
- Density
- 0.95 g/mL at 25 °C
- refractive index
- 68 ° (C=1, MeOH)
- Flash point:
- 40 °F
- storage temp.
- room temp
- solubility
- soluble in Chloroform, Methanol
- pka
- 1.02±0.40(Predicted)
- form
- Liquid
- color
- Colorless to amber
- optical activity
- [α]22/D +76.8°, c = 1 in toluene
- Water Solubility
- Not miscible or difficult to mix in water.
- Sensitive
- Air & Moisture Sensitive
- BRN
- 9059874
- Exposure limits
- ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) - InChIKey
- VMKAFJQFKBASMU-QGZVFWFLSA-N
- CAS DataBase Reference
- 112022-83-0(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 11-38-48/20-63-65-67-36/37-19-40
- Safety Statements
- 36/37-62-33-29-16-2-26
- RIDADR
- UN 1294 3/PG 2
- WGK Germany
- 3
- F
- 10
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29319090
MSDS
- Language:English Provider:(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Usage And Synthesis
Reactions
- Convenient catalyst for the enantioselective borane reduction of ketones at ambient temperatures.
- Asymmetric synthesis of α-chiral hydroxyalkylphosphines via a catalytic, enantioselective reduction of acylphosphines.
- Nickel-catalyzed cross-couplings of benzylic pivalates with arylboroxines: Stereospecific formation of diarylalkanes and triarylmethanes.
- Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS.
Chemical Properties
white to light yellow crystal powde
Uses
suzuki reaction
Uses
(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols.
Uses
CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Preparation Products And Raw materials
Preparation Products
(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaboroleSupplier
ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. Gold
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- 023-89130144 18523560356
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Shanghai Forxine Pharmaceutical Co., Ltd. Gold
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- 21-21-64961388 18918697718
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Jiangsu Greature Bio-Medicine Co., Ltd. Gold
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- 0512-0512-85557988 18852406663
- frank.wang@greature.com.cn
Viwit Pharmaceutical Co., Ltd. Gold
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- 0632-2980981 15063270987
- service.china3@viwit.com
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
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(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole(112022-83-0)Related Product Information
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