NIKKOMYCIN Z
NIKKOMYCIN Z Basic information
- Product Name:
- NIKKOMYCIN Z
- Synonyms:
-
- NIKKOMYCIN
- NIKKOMYCIN Z
- NIKKOMYCIN Z, STREPTOMYCES TENDAE
- (2s-(2r*,3r*,4r*))-l)
- 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-beta-d-allofuranuronicaci
- methyl-1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-dioxo-1(2h)-pyrimidiny
- neopolyoxinc
- nikkomycin Z from streptomyces tendae
- CAS:
- 59456-70-1
- MF:
- C20H25N5O10
- MW:
- 495.44
- Product Categories:
-
- AntifungalGlycobiology
- InhibitorsAntibiotics
- Peptidyl Nucleosides
- Antibiotics
- Peptidyl NucleosidesMore...Close...
- Inhibitors and Substrates
- Antibiotics A to
- Antibiotics N-SAntibiotics
- AntifungalAntibiotics
- Chemical Structure Class
- Inhibits an EnzymeAntibiotics
- Interferes with Cell Wall SynthesisAntibiotics
- Mechanism of Action
- Spectrum of Activity
- Mol File:
- 59456-70-1.mol
NIKKOMYCIN Z Chemical Properties
- Density
- 1.646±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble5mg/mL
- pka
- 2.70±0.10(Predicted)
- Water Solubility
- Water : ≥ 100 mg/mL (201.84 mM)
NIKKOMYCIN Z Usage And Synthesis
Description
Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
Uses
Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
Definition
ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
Pharmacology
By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
Metabolism
There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
NIKKOMYCIN ZSupplier
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NIKKOMYCIN Z(59456-70-1)Related Product Information
- NIKKOMYCIN Z
- PROPYL-(TETRAHYDRO-FURAN-2-YLMETHYL)-AMINE
- D-HOMOCITRULLINE
- (S)-(+)-Tetrahydrofurfurylamine
- GLYCYL-D-THREONINE DIHYDRATE
- AC-D-NLE-OH
- GLYCYL-D-SERINE
- (2R,3S)-2-AMINO-3-HYDROXY-HEXANOIC ACID
- 4-PYRIDIN-2-YL-BUTYLAMINE
- Nikkomycin M
- dl-3-hydroxynorvaline
- AC-D-LYS-OH
- GLYCYL-D-THREONINE
- Nikkomycin N
- Nikkomycin J
- Nikkomycin pseudo-J
- nikkomycin L(z)
- nikkomycin L(x)