PHOSPHONOACETIC ACID Chemical Properties

Melting point:

143-146 °C (lit.)

Boiling point:

490.2±47.0 °C(Predicted)

Density 

1.858±0.06 g/cm3(Predicted)

refractive index 

1.5180 (estimate)

storage temp. 

2-8°C

solubility 

water: soluble100mg/mL, clear to very slightly hazy, colorless

pka

1.74±0.10(Predicted)

form 

Solid

color 

White to off-white

Water Solubility 

Soluble in water.

Sensitive 

Hygroscopic

BRN 

1764355

CAS DataBase Reference

4408-78-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

26-36/37/39

RIDADR 

UN3261

WGK Germany 

3

RTECS 

AJ3278000

HazardClass 

8

PackingGroup 

III

HS Code 

29319019

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

PHOSPHONOACETIC ACID Usage And Synthesis

Chemical Properties

White powder

Uses

Antiviral.

Uses

Phosphonoacetic acid inhibits deoxyribo nucleic acid polymerase, especially in viruses. It is used as an antiviral agent. Further, it is used in the preparation of 1-(dimethylamino)-2,2-bis[(dimethylimmonio)-methyl]ethene diperchlorate by reacting with phosphorus oxychloride.

Uses

Phosphonoacetic acid was used as an inhibitor of viral DNA replication, to investigate the infected cell protein 0 (bICP0) localization in infected low passage bovine cells. It was also used as a phosphorus source for microbial growth in phosphate-independent manner.

Definition

ChEBI: A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

PHOSPHONOACETIC ACID(4408-78-0)Related Product Information

• TRIETHYL 2-PHOSPHONOPENTANOATE
• tert-Butyl 2-(dimethoxyphosphoryl)acetate
• BIS(2,2,2-TRIFLUOROETHYL)PHOSPHONOACETIC ACID METHYL ESTER
• 2-PHOSPHONOPROPIONIC ACID
• Triethyl phosphonobromoacetate
• DIETHYLPHOSPHONOACETIC ACID
• TRIMETHYLSILYL DIETHYLPHOSPHONOACETATE
• 2-CHLORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER
• PHOSPHONOACETIC ACID
• PHOSPHONOACETIC ACID P,P-DIMETHYL ETHYL ESTER,Ethoxycarbonylmethylphosphonic acid dimethylester, Phosphonoacetic acid P,P-dimethyl ethylester
• tert-Butyl diethylphosphonoacetate
• TRIETHYL 2-PHOSPHONOBUTYRATE
• PHOSPHONOACETIC ACID TRIMETHYL ESTER
• PHOSPHONOACETIC ACID TRIETHYL ESTER
• 2-PHOSPHONOBUTYRIC ACID
• TRIETHYL 2-PHOSPHONOPROPIONATE
• 2-Fluoro-2-phosphonoacetic acid triethyl ester 96%,2-FLUORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER 95+%,2-FLUORO-2-PHOSPHONOACETIC ACID TRIETHYL ESTER
• phosphonoacetic acid diethyl methyl ester