TRIETHYL 2-PHOSPHONOBUTYRATE Chemical Properties

Boiling point:

152-154 °C14 mm Hg(lit.)

Density 

1.064 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.432(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

Specific Gravity

1.064

color 

Clear colorless

Water Solubility 

Not miscible or difficult to mix with water.

BRN 

1789280

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29310099

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TRIETHYL 2-PHOSPHONOBUTYRATE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Uses

Reactant for preparation of:

• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis

TRIETHYL 2-PHOSPHONOBUTYRATE(17145-91-4)Related Product Information

• Triethylamine trihydrofluoride
• triisopropylsilyl Methacrylate
• acetic acid, triethoxy-, ethyl ester
• TRIISOPROPYLSILYL TRIFLUOROMETHANESULFONATE
• Triethyloxonium tetrafluoroborate
• TRIETHYL 2-PHOSPHONOPROPIONATE
• 2-PHOSPHONOBUTYRIC ACID
• TRIETHYL 4-PHOSPHONOBUTYRATE
• TRIETHYL ALPHA-PROPARGYLPHOSPHONOACETATE
• 2-(DIETHOXYPHOSPHINYL)-3-METHYLBUTANOIC ACID ETHYL ESTER
• TRIETHYL 2-PHOSPHONOPENTANOATE
• 1-Ethyl 4-(tert-Butyl) 2-(diethyl phosphono)succinate
• TRIETHYL 2-PHOSPHONOBUTYRATE