TRIETHYL 2-PHOSPHONOBUTYRATE Chemical Properties

Boiling point:

152-154 °C14 mm Hg(lit.)

Density 

1.064 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.432(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

Specific Gravity

1.064

color 

Clear colorless

Water Solubility 

Not miscible or difficult to mix with water.

BRN 

1789280

InChI

InChI=1S/C10H21O5P/c1-5-9(10(11)13-6-2)16(12,14-7-3)15-8-4/h9H,5-8H2,1-4H3

InChIKey

GYUCVQSNZFRDRL-UHFFFAOYSA-N

SMILES

C(OCC)(=O)C(P(OCC)(OCC)=O)CC

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29310099

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TRIETHYL 2-PHOSPHONOBUTYRATE Usage And Synthesis

Chemical Properties

clear colorless liquid

Uses

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

Uses

Reactant for preparation of:

• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
• α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
• Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
• Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis

reaction suitability

reaction type: C-C Bond Formation

TRIETHYL 2-PHOSPHONOBUTYRATE(17145-91-4)Related Product Information

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