4-Aminophenylacetonitrile Chemical Properties

Melting point:

45-48 °C(lit.)

Boiling point:

312 °C(lit.)

Density 

1.4747 (rough estimate)

refractive index 

1.6231 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

soluble in Methanol

pka

4.25±0.10(Predicted)

form 

Crystalline Powder, Crystals or Chunks

color 

Yellow to brown

Water Solubility 

SLIGHTLY SOLUBLE

BRN 

1100108

Exposure limits

NIOSH: IDLH 25 mg/m3

InChIKey

YCWRFIYBUQBHJI-UHFFFAOYSA-N

CAS DataBase Reference

3544-25-0(CAS DataBase Reference)

NIST Chemistry Reference

4-Aminophenylacetic acid nitrile(3544-25-0)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36-36/37

RIDADR 

3276

WGK Germany 

3

Hazard Note 

Harmful

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269095

MSDS

• Language:English Provider:4-Aminophenylacetonitrile
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Aminophenylacetonitrile Usage And Synthesis

Chemical Properties

yellow to brown crystalline powder, crystals

Uses

4-Aminobenzyl Cyanide can be used to prevent or treat influenza.

Synthesis Reference(s)

Synthetic Communications, 22, p. 3189, 1992 DOI: 10.1080/00397919208021132

Synthesis

P-Nitrophenylacetonitrile (10 g, 61.67 mmol) was dissolved in methanol (50 mL). Add 10 per cent Pd/C (1.0g), Replace the reaction system four times with H2, and Stir at room temperature overnight in an H2 environment (0.5 MPa).TLC analysis, the reaction was complete, and the reaction solution was filtered through celite. The filtrate was concentrated under reduced pressure to give 8.08g of 4-Aminophenylacetonitrile; the yield was 99.1 per cent.

References

[1] Tetrahedron Letters, 1984, vol. 25, # 45, p. 5219 - 5222
[2] Tetrahedron Letters, 1984, vol. 25, # 45, p. 5219 - 5222
[3] Organometallics, 2017, vol. 36, # 16, p. 3110 - 3116
[4] Applied Organometallic Chemistry, 2018, vol. 32, # 1,
[5] Tetrahedron Letters, 2001, vol. 42, # 12, p. 2285 - 2288

4-Aminophenylacetonitrile(3544-25-0)Related Product Information

• Sulfanilamide
• Sodium 4-aminosalicylate
• 4-Aminophenol
• 4-Aminobenzoic acid
• Sulfanilic acid
• Cupric acetate monohydrate
• Dichloromethane
• 1-(CHLOROMETHYL)-3,5-BIS(METHYLSULFONYL)BENZENE
• Cyclopentane
• Indigo
• Glucosamine
• 4-Aminophenylacetic acid
• p-Aminobenzamide
• 4-Aminosalicylic acid
• 2-(4-Aminophenyl)ethylamine
• 2-PHENYLGLYCINONITRILE HYDROCHLORIDE
• 2-PHENYLGLYCINONITRILE HYDROCHLORIDE
• 2-Aminobenzyl cyanide