Bromoacetamido-PEG5-DOTA Chemical Properties

Boiling point:

976.6±65.0 °C(Predicted)

Density 

1.314±0.06 g/cm3(Predicted)

pka

1.83±0.10(Predicted)

form 

Oil

color 

White to off-white

Bromoacetamido-PEG5-DOTA Usage And Synthesis

Description

Bromoacetamido-PEG3-DOTA is a PEG linker containing a bromine moiety and a t-butyl protecting group. The hydrophilic PEG spacer increases the water solubility of a compound in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The DOTA group can be ionized and is susceptible for chelating di- and trivalent cations.

Uses

Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromoacetamido-PEG5-DOTA(2353410-19-0)Related Product Information

• BrCH2CONH-PEG1-NHS ester
• BrCH2CONH-PEG5-NHS ester
• Bromoacetamido-PEG2-AZD
• BrCH2CONH-PEG6-OMe
• BrCH2CONH-PEG3-NHS ester
• INDEX NAME NOT YET ASSIGNED
• BrCH2CONH-PEG3-OMe
• Bromoacetamido-PEG2- NHS ester
• 4,7,10,13,16,19,22,25-Octaoxa-28-azatriacontanoic acid, 30-bromo-29-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
• Acetamide, 2-bromo-N-[2-(2-methoxyethoxy)ethyl]-
• BrCH2CONH-PEG9-NHS ester
• BrCH2CONH-PEG3-CONH-DBCO
• Bromoacetamido-PEG3-AZD
• BrCH2CONH-PEG7-CONH-DBCO
• BrCH2CONH-PEG7-TFP ester
• BrCH2CONH-PEG7-NHBoc
• BrCH2CONH-PEG9-NHBoc
• BrCH2CONH-PEG6-NHS ester