Bromoacetamido-PEG2- NHS ester Chemical Properties

Density 

1.52±0.1 g/cm3(Predicted)

storage temp. 

Storage temp. -20°C

form 

Liquid

pka

13.20±0.46(Predicted)

color 

Colorless to light yellow

Bromoacetamido-PEG2- NHS ester Usage And Synthesis

Description

Bromoacetamido-PEG2-NHS ester is a PEG linker containing a bromide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Uses

Bromoacetamido-PEG2-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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