Bromo-PEG2-acid Chemical Properties

Boiling point:

347.2±27.0 °C(Predicted)

Density 

1.464±0.06 g/cm3(Predicted)

storage temp. 

-20°C

pka

4.27±0.10(Predicted)

form 

Liquid

color 

Light brown to yellow

Safety Information

HS Code 

2918999090

Bromo-PEG2-acid Usage And Synthesis

Description

Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bromo-PEG₂-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₂-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.

Bromo-PEG2-acid(1807503-92-9)Related Product Information

• Br-PEG3-CH2CO2H
• Bromo-PEG1-t-butyl ester
• 1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE
• DIETHYL BROMOMALONATE
• NEOPENTYLBORONIC ACID
• Chloromethyl pivalate
• Cyclopropyl bromide
• 2-Bromomethyl-1,3-dioxolane
• Bromo-PEG6-alcohol
• 3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-
• Bromo-PEG8-t-butyl ester
• Ethanol, 2-[2-(2-bromoethoxy)ethoxy]-
• Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-
• Ethanol, 2-(2-bromoethoxy)-
• Bromo-PEG4-acid
• Bromo-PEG4-t-butyl ester
• Bromo-PEG2-azide
• Ethylene glycol