Bromo-PEG4-acid Chemical Properties

Boiling point:

426.9±40.0 °C(Predicted)

Density 

1.352±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in Water, DMSO, DMF, DCM

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Bromo-PEG4-acid Usage And Synthesis

Description

Bromo-PEG4-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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