Bromo-PEG4-t-butyl ester Chemical Properties

Boiling point:

415.8±35.0 °C(Predicted)

Density 

1.210±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DMSO, DCM, DMF

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C15H29BrO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13H2,1-3H3

InChIKey

WLKHUFASPMJBHB-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCBr

Bromo-PEG4-t-butyl ester Usage And Synthesis

Description

Bromo-PEG4-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Biological Activity

Br-PEG4-C2-Boc is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC).

target

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Robert Yongxin Zhao, et al. Cytotoxic agents. WO2003068144A2.

Bromo-PEG4-t-butyl ester(564476-32-0)Related Product Information

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