H2N-PEG4-tBu Chemical Properties

Boiling point:

400.1±35.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in Water, DMSO, DCM, DMF

form 

clear liquid

pka

8.74±0.10(Predicted)

color 

Colorless to Light yellow

CAS DataBase Reference

581065-95-4

Safety Information

HS Code 

2922190090

H2N-PEG4-tBu Usage And Synthesis

Description

Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.

Uses

is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds.

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