H2N-PEG4-tBu
- Product Name
- H2N-PEG4-tBu
- CAS No.
- 581065-95-4
- Chemical Name
- H2N-PEG4-tBu
- Synonyms
- tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate;H2N-PEG4-tBu;NH2-PEG4-TBA;Amino-PEG4-Boc;Amino-PEG4-COOtBu;NH2-PEG4-C2-COOtBu;Amino-PEG4-Boc (HQ);NH2-PEG4-CH2CH2COtBu;H2N-PEG4-CH2CH2COOtBu;NH2-PEG4-CH2CH2COOtBu
- CBNumber
- CB02546867
- Molecular Formula
- C15H31NO6
- Formula Weight
- 321.41
- MOL File
- 581065-95-4.mol
H2N-PEG4-tBu Property
- Boiling point:
- 400.1±35.0 °C(Predicted)
- Density
- 1.040±0.06 g/cm3(Predicted)
- refractive index
- n/D 1.4508
- storage temp.
- -20°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- clear liquid
- pka
- 8.74±0.10(Predicted)
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
- InChIKey
- PKESARRNSGIDRD-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCN
- CAS DataBase Reference
- 581065-95-4
Safety
- WGK Germany
- WGK 3
- HS Code
- 2922190090
- Storage Class
- 10 - Combustible liquids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 902535
- Product name
- Amino-PEG4-t-butyl ester
- Packaging
- 250MG
- Price
- $178
- Updated
- 2026/03/19
- Product number
- 902535
- Product name
- Amino-PEG4-t-butyl ester
- Packaging
- 1G
- Price
- $643
- Updated
- 2026/03/19
- Product number
- B5900
- Product name
- tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
- Purity
- >95.0%(T)
- Packaging
- 250mg
- Price
- $81
- Updated
- 2026/03/19
- Product number
- B5900
- Product name
- tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
- Purity
- >95.0%(T)
- Packaging
- 1g
- Price
- $244
- Updated
- 2026/03/19
- Product number
- 41713
- Product name
- tert-Butyl1-amino-3,6,9,12-tetraoxapentadecan-15-oate,95%(Assaybytitration)
- Purity
- 95%(Assaybytitration)
- Packaging
- 250MG
- Price
- $81.76
- Updated
- 2021/12/16
H2N-PEG4-tBu Chemical Properties,Usage,Production
Description
Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.
Uses
is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds.
reaction suitability
reagent type: cross-linking reagent
Synthesis
581065-94-3
581065-95-4
The general procedure for the synthesis of tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate from 1-(p-toluenesulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate is as follows: 150 g of the sulfonated crude product was dissolved in 200 mL of methylene chloride, followed by the addition of 100 g of ammonium hydroxide and 10 g of tetrabutyl ammonium bromide. The reaction mixture was warmed to 40 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation. To the residue, 3 M hydrochloric acid solution was added and the pH was adjusted to 3. The organic phase was separated by extracting twice with 300 mL of dichloromethane. The pH of the aqueous phase was then adjusted to 9 with sodium hydroxide solution and extracted three times with 400 mL of dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation to give 50 g of aminocapped product. The structure of the product was confirmed by NMR.
IC 50
PEGs; Alkyl/ether
References
[1] Patent: WO2012/166560, 2012, A1
[2] Patent: WO2013/192360, 2013, A1
[3] Patent: WO2013/185117, 2013, A1
[4] Patent: CN107235848, 2017, A. Location in patent: Paragraph 0021
H2N-PEG4-tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from H2N-PEG4-tBu manufacturers
- Product
- NH2-PEG4-COOtBu 581065-95-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-06
- Product
- NH2-PEG4-CH2CH2COOtBu 581065-95-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2026-01-28
- Product
- tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate 581065-95-4
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2025-09-12