ChemicalBook > CAS DataBase List > H2N-PEG4-tBu

H2N-PEG4-tBu

Product Name
H2N-PEG4-tBu
CAS No.
581065-95-4
Chemical Name
H2N-PEG4-tBu
Synonyms
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate;H2N-PEG4-tBu;NH2-PEG4-TBA;Amino-PEG4-Boc;Amino-PEG4-COOtBu;NH2-PEG4-C2-COOtBu;NH2-PEG4-CH2CH2COtBu;H2N-PEG4-CH2CH2COOtBu;NH2-PEG4-CH2CH2COOtBu;NH2-PEG4-(CH2)2COOtBu
CBNumber
CB02546867
Molecular Formula
C15H31NO6
Formula Weight
321.41
MOL File
581065-95-4.mol
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H2N-PEG4-tBu Property

Boiling point:
400.1±35.0 °C(Predicted)
Density 
1.040±0.06 g/cm3(Predicted)
refractive index 
n/D 1.4508
storage temp. 
-20°C
solubility 
Soluble in Water, DMSO, DCM, DMF
form 
clear liquid
pka
8.74±0.10(Predicted)
color 
Colorless to Light yellow
InChI
InChI=1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
InChIKey
PKESARRNSGIDRD-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCN
CAS DataBase Reference
581065-95-4
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Safety

HS Code 
2922190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
902535
Product name
Amino-PEG4-t-butyl ester
Packaging
250MG
Price
$116.9
Updated
2025/07/31
Sigma-Aldrich
Product number
902535
Product name
Amino-PEG4-t-butyl ester
Packaging
1G
Price
$604
Updated
2025/07/31
TCI Chemical
Product number
B5900
Product name
tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
Purity
>95.0%(T)
Packaging
250mg
Price
$81
Updated
2025/07/31
TCI Chemical
Product number
B5900
Product name
tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
Purity
>95.0%(T)
Packaging
1g
Price
$244
Updated
2025/07/31
AK Scientific
Product number
0436AP
Product name
H2N-PEG4-tBu
Packaging
1g
Price
$255
Updated
2021/12/16
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H2N-PEG4-tBu Chemical Properties,Usage,Production

Description

Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.

Uses

is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds.

reaction suitability

reagent type: cross-linking reagent

Synthesis

581065-94-3

581065-95-4

The general procedure for the synthesis of tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate from 1-(p-toluenesulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate is as follows: 150 g of the sulfonated crude product was dissolved in 200 mL of methylene chloride, followed by the addition of 100 g of ammonium hydroxide and 10 g of tetrabutyl ammonium bromide. The reaction mixture was warmed to 40 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation. To the residue, 3 M hydrochloric acid solution was added and the pH was adjusted to 3. The organic phase was separated by extracting twice with 300 mL of dichloromethane. The pH of the aqueous phase was then adjusted to 9 with sodium hydroxide solution and extracted three times with 400 mL of dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation to give 50 g of aminocapped product. The structure of the product was confirmed by NMR.

IC 50

PEGs; Alkyl/ether

References

[1] Patent: WO2012/166560, 2012, A1
[2] Patent: WO2013/192360, 2013, A1
[3] Patent: WO2013/185117, 2013, A1
[4] Patent: CN107235848, 2017, A. Location in patent: Paragraph 0021

H2N-PEG4-tBu Preparation Products And Raw materials

Raw materials

Preparation Products

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H2N-PEG4-tBu Suppliers

Americas 1 China 162 Europe 1 India 3 Japan 1 United Kingdom 2 United States 12 Global 182
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from H2N-PEG4-tBu manufacturers

LAURENT
Product
NH2-PEG4-CH2CH2COOtBu 581065-95-4
Price
US $44.80/g
Min. Order
10g
Purity
98%
Supply Ability
300kg
Release date
2025-11-15
XIAMEN SINOPEG BIOTECH CO., LTD.
Product
tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate 581065-95-4
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
1g/bottle, 10g/bottle, 100g/bottle
Release date
2025-09-12
Xian confluore Biological Technology Co., Ltd.
Product
Amino-PEG4-COOtBu 581065-95-4
Price
US $0.00/g
Min. Order
25g
Purity
>98.00%
Supply Ability
25g
Release date
2024-04-02

581065-95-4, H2N-PEG4-tBuRelated Search:

1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)- 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL Biotin-PEG3-N3 O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine DODECAETHYLENE GLYCOL MONOMETHYL ETHER Fmoc-NH-PEG3-CH2COOH N3-PEG3-tBu 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine Z-8-aMino-3,6-dioxaoctanoic acid HO-PEG8-CH2CH2COOH 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol HS-PEG4-tBu O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester Amino-PEG6-alcohol 4-MALEIMIDOBUTYRIC ACID

  • H2N-PEG4-tBu
  • tert-Butyl 15-aMino-4,7,10,13-tetraoxapentadecanoate
  • 2-[2-[2-[2-(2-tert-Butoxycarbonylethoxy)ethoxy]ethoxy]ethoxy]ethylamine
  • H<sub>2</sub>N-PEG<sub>4</sub>-CH<sub>2</sub>CH<sub>2</sub>COO<sup>t</sup>Bu
  • Amino-dPEG4-t-butyl ester
  • tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate
  • H2N-PEG4-CH2CH2COOtBu
  • Amino-PEG4-t-butyl ester
  • 15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butylester
  • NH2-PEG4-CH2CH2COOtBu
  • tert-Butyl 1-Amino-3,6,9,12-tetraoxa-15-pentadecanoate
  • AMINO-PEG4-PROPANOIC ACID T-BUTYL ESTER
  • H2N-PEG4-CH2CH2-t-butylester
  • Amino-PEG4-COOtBu
  • Amino-PEG4-Boc
  • 4,7,10,13-Tetraoxapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester
  • 1-Amino-3,6,9,12-tetraoxapentadecan-15-oic Acid tert-Butyl Ester
  • NH2-PEG4-(CH2)2COOtBu
  • 15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butyleste
  • H?N-PEG?-CH?CH?COOtBu
  • tert-butyl3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate
  • Amino-PEG4-t-Bu Ester
  • H2N-PEG4-CH2CH2COOtBu/4,7,10,13-Tetraoxapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester
  • NH2-PEG4-C2-COOtBu
  • NH2-PEG4-CH2CH2COtBu
  • Amino-dPEG??-t-butyl ester (QBD-10221)
  • NH2-PEG4-TBA
  • 581065-95-4
  • PEG-COOtBu
  • peg