ChemicalBook > CAS DataBase List > H2N-PEG4-tBu

H2N-PEG4-tBu

Product Name: H2N-PEG4-tBu
CAS No.: 581065-95-4
Chemical Name: H2N-PEG4-tBu
Synonyms: tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate;H2N-PEG4-tBu;NH2-PEG4-TBA;Amino-PEG4-Boc;Amino-PEG4-COOtBu;NH2-PEG4-C2-COOtBu;NH2-PEG4-CH2CH2COtBu;H2N-PEG4-CH2CH2COOtBu;NH2-PEG4-CH2CH2COOtBu;NH2-PEG4-(CH2)2COOtBu
CBNumber: CB02546867
Molecular Formula: C15H31NO6
Formula Weight: 321.41
MOL File: 581065-95-4.mol

Less

H2N-PEG4-tBu Property

Boiling point:: 400.1±35.0 °C(Predicted)
Density: 1.040±0.06 g/cm3(Predicted)
refractive index: n/D 1.4508
storage temp.: -20°C
solubility: Soluble in Water, DMSO, DCM, DMF
form: clear liquid
pka: 8.74±0.10(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
InChIKey: PKESARRNSGIDRD-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCN
CAS DataBase Reference: 581065-95-4

Less

Safety

HS Code: 2922190090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 902535
Product name: Amino-PEG4-t-butyl ester
Packaging: 250MG
Price: $116.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 902535
Product name: Amino-PEG4-t-butyl ester
Packaging: 1G
Price: $604
Updated: 2025/07/31

TCI Chemical

Product number: B5900
Product name: tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
Purity: >95.0%(T)
Packaging: 250mg
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: B5900
Product name: tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate
Purity: >95.0%(T)
Packaging: 1g
Price: $244
Updated: 2025/07/31

AK Scientific

Product number: 0436AP
Product name: H2N-PEG4-tBu
Packaging: 1g
Price: $255
Updated: 2021/12/16

Less

H2N-PEG4-tBu Chemical Properties,Usage,Production

Description

Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.

Uses

is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds.

reaction suitability

reagent type: cross-linking reagent

Synthesis

581065-94-3

581065-95-4

The general procedure for the synthesis of tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate from 1-(p-toluenesulfonyloxy)-3,6,9,12-tetraoxapentadecan-15-oate is as follows: 150 g of the sulfonated crude product was dissolved in 200 mL of methylene chloride, followed by the addition of 100 g of ammonium hydroxide and 10 g of tetrabutyl ammonium bromide. The reaction mixture was warmed to 40 °C with continuous stirring for 24 hours. Upon completion of the reaction, the solvent was removed by rotary evaporation. To the residue, 3 M hydrochloric acid solution was added and the pH was adjusted to 3. The organic phase was separated by extracting twice with 300 mL of dichloromethane. The pH of the aqueous phase was then adjusted to 9 with sodium hydroxide solution and extracted three times with 400 mL of dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by rotary evaporation to give 50 g of aminocapped product. The structure of the product was confirmed by NMR.

IC 50

PEGs; Alkyl/ether

References

[1] Patent: WO2012/166560, 2012, A1
[2] Patent: WO2013/192360, 2013, A1
[3] Patent: WO2013/185117, 2013, A1
[4] Patent: CN107235848, 2017, A. Location in patent: Paragraph 0021

H2N-PEG4-tBu Preparation Products And Raw materials

Raw materials

Preparation Products

Less

H2N-PEG4-tBu Suppliers

Americas 1 China 162 Europe 1 India 3 Japan 1 United Kingdom 2 United States 12 Global 182

Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
Advantage: 58

Shanghai Yanfen Biochemical Technology Co.,LTD

Tel: 17721070236 15002190549;
Email: yanfen2023@126.com
Country: China
ProdList: 1837
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

Changsha Morning Shine Co., Ltd.

Tel: 189-75832125 13397510867
Email: BD@csmspharm.com
Country: China
ProdList: 399
Advantage: 58

Anhui Yongsheng Pharmaceutical Technology Co., Ltd

Tel: 181-3307-5798 18017383231
Email: 983544897@qq.com
Country: China
ProdList: 921
Advantage: 58

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 497
Advantage: 58

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Shanghai Boka-chem Tech. Inc.

Tel: 400-026-1533/(021) 6478-0600
Fax: +86 (21) 6459-2060
Email: sales@bokachem.com
Country: China
ProdList: 876
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Tongling HengYou Biotechnology Co., Ltd.

Tel: 021-50426030 13856289449
Fax: 021-50426030
Email: 2630597085@qq.com
Country: China
ProdList: 1889
Advantage: 55

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
ProdList: 1245
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10109
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 021-68882955 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 4992
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Hangzhou HanLai Biochemical Technology Co., Ltd.

Tel: 571-86101219 18768477782
Fax: -
Email: sales09@leobiochem.com
Country: China
ProdList: 433
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9721
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Abydos Scientific

Tel: 025-84767922 18936879710
Email: sales@abydoscientific.com
Country: China
ProdList: 1002
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Alpha Biopharmaceuticals Co., Ltd

Tel: 0411-39042497
Fax: 0411-39042693
Email: sales@alphabiopharm.com
Country: China
ProdList: 1951
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

TCI Chemicals

Tel: 021-67121386, 800-988-0390
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 5391
Advantage: 58

Less

View Lastest Price from H2N-PEG4-tBu manufacturers

LAURENT

Product: NH2-PEG4-CH2CH2COOtBu 581065-95-4
Price: US $44.80/g
Min. Order: 10g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-15

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: tert-butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate 581065-95-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-12

Xian confluore Biological Technology Co., Ltd.

Product: Amino-PEG4-COOtBu 581065-95-4
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 25g
Release date: 2024-04-02

581065-95-4, H2N-PEG4-tBuRelated Search:

1H-Thieno[3,4-d]imidazole-4-pentanamide,N-(14-amino-3,6,9,12-tetraoxatetradec-1-yl)hexahydro-2-oxo-,(3aS,4S,6aR)- 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL Biotin-PEG3-N3 O-(2-AMINOETHYL)-O-(2-AZIDOETHYL)HEPTAETHYLENE GLYCOL 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-amine DODECAETHYLENE GLYCOL MONOMETHYL ETHER Fmoc-NH-PEG3-CH2COOH N3-PEG3-tBu 2,5,8,11,14,17,20,23-Octaoxapentacosane-25-thiol 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine Z-8-aMino-3,6-dioxaoctanoic acid HO-PEG8-CH2CH2COOH 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol HS-PEG4-tBu O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) 5,8,11,14-Tetraoxa-2-azahexadecanoic acid,16-amino-,1,1-dimethyl ester Amino-PEG6-alcohol 4-MALEIMIDOBUTYRIC ACID

H2N-PEG4-tBu

tert-Butyl 15-aMino-4,7,10,13-tetraoxapentadecanoate

2-[2-[2-[2-(2-tert-Butoxycarbonylethoxy)ethoxy]ethoxy]ethoxy]ethylamine

H2N-PEG4-CH2CH2COOtBu

Amino-dPEG4-t-butyl ester

tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate

H2N-PEG4-CH2CH2COOtBu

Amino-PEG4-t-butyl ester

15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butylester

NH2-PEG4-CH2CH2COOtBu

tert-Butyl 1-Amino-3,6,9,12-tetraoxa-15-pentadecanoate

AMINO-PEG4-PROPANOIC ACID T-BUTYL ESTER

H2N-PEG4-CH2CH2-t-butylester

Amino-PEG4-COOtBu

Amino-PEG4-Boc

4,7,10,13-Tetraoxapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester

1-Amino-3,6,9,12-tetraoxapentadecan-15-oic Acid tert-Butyl Ester

NH2-PEG4-(CH2)2COOtBu

15-Amino-4,7,10,13-tetraoxa-pentadecanoic-acid-tert-butyleste

H?N-PEG?-CH?CH?COOtBu

tert-butyl3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate

Amino-PEG4-t-Bu Ester

H2N-PEG4-CH2CH2COOtBu/4,7,10,13-Tetraoxapentadecanoic acid, 15-amino-, 1,1-dimethylethyl ester

NH2-PEG4-C2-COOtBu

NH2-PEG4-CH2CH2COtBu

Amino-dPEG??-t-butyl ester (QBD-10221)

NH2-PEG4-TBA

581065-95-4

PEG-COOtBu

peg