HS-PEG4-tBu Chemical Properties

Boiling point:

414.6±40.0 °C(Predicted)

Density 

1.060±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

Liquid

pka

9?+-.0.10(Predicted)

color 

Colorless to light yellow

HS-PEG4-tBu Usage And Synthesis

Description

Thiol-PEG4-t-butyl ester is a PEG linker containing a thiol group and a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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