3,6,9,12-tetraoxatridecylamine Chemical Properties

Boiling point:

85°C/0.1mmHg(lit.)

Density 

1.005±0.06 g/cm3(Predicted)

refractive index 

1.4440 to 1.4480

storage temp. 

-20°C

form 

solid or viscous liquid

pka

8.74±0.10(Predicted)

color 

Colorless to Almost colorless

InChI

InChI=1S/C9H21NO4/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h2-10H2,1H3

InChIKey

DQTQYVYXIOQYGN-UHFFFAOYSA-N

SMILES

C(N)COCCOCCOCCOC

Safety Information

RIDADR 

UN 2735 8/PG III

HS Code 

2922.19.9690

HazardClass 

8

PackingGroup 

III

3,6,9,12-tetraoxatridecylamine Usage And Synthesis

Description

m-PEG4-amine is a PEG reagent containing an amino (NH2) group. NH2 group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Uses

m-PEG4-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

reaction suitability

reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: carboxyl reactive

IC 50

Cleavable Linker; PEGs

References

[1] Hervé Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.

3,6,9,12-tetraoxatridecylamine (85030-56-4)Related Product Information

• 13-Azido-2,5,8,11-tetraoxa-tridecane
• Biotin-PEG4-N3
• 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47-Hexadecaoxanonatetracontan-49-ol
• alpha-aMine-oMega-propionic acid dodecaethylene glycol
• Biotin-PEG3-propionic acid
• N3-PEG6-tBu
• alpha-MaleiMidopropionyl-oMega-succiniMidyl-12(ethylene glycol)
• MPEG16-NH2
• FMOC-GAMMA-ABU-OH
• TETRAETHYLENEGLYCOL MONOMETHYL ETHER
• Diethylene Glycol 2-Bromoethyl Methyl Ether
• Methyl-PEG4-Acyl Chloride
• m-PEG5-bromide
• HEPTAETHYLENE GLYCOL MONOMETHYL ETHER
• 3,6,9,12,15,18,21,24-Octaoxapentacosan-1-amine
• Methyl-PEG3-ALD
• HEXAETHYLENE GLYCOL MONOMETHYL ETHER
• PENTAETHYLENE GLYCOL MONOMETHYL ETHER