TETRAETHYLENEGLYCOL MONOMETHYL ETHER Chemical Properties

Boiling point:

158-160 °C (5 mmHg)

Density 

1.045 g/mL at 25 °C

vapor pressure 

0.1Pa at 20℃

refractive index 

1.444-1.446

Flash point:

>110°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO

form 

Liquid

pka

14.36±0.10(Predicted)

color 

Clear colorless to very slightly yellow

Water Solubility 

Water solubility 999,999c.

α-end

methoxy

Ω-end

hydroxyl

InChIKey

ZNYRFEPBTVGZDN-UHFFFAOYSA-N

LogP

-1.5 at 20℃

CAS DataBase Reference

23783-42-8(CAS DataBase Reference)

EPA Substance Registry System

2,5,8,11-Tetraoxatridecan-13-ol (23783-42-8)

Safety Information

Safety Statements 

24/25-22

WGK Germany 

1

TSCA 

Yes

HS Code 

29094990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

TETRAETHYLENEGLYCOL MONOMETHYL ETHER Usage And Synthesis

Description

m-PEG4-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Chemical Properties

CLEAR COLOURLESS TO VERY SLIGHTLY YELLOW LIQUID

Uses

2,5,8,11-Tetraoxatridecan-13-o1, can be used in the synthesis of various chemicla compounds. It is also a monofunctional PEG that can be used in polymer science.

Definition

ChEBI: 5S,6S-epoxy-15R-hydroxy-ETE is a poly(ethylene glycol).

Synthesis

General procedure: Tetraethylene glycol monomethyl ether was synthesized from the compound (CAS: 727986-31-4). This was done as follows: to a solution of 2-(2,5,8,11-tetraoxatridecan-13-yloxy)tetrahydro-2H-pyran (280 mg, 0.96 mmol) in methanol (5 mL) was added pyridinium salt of p-toluenesulfonate (PPTS, 24 mg, 0.096 mmol) at 0 °C. The reaction mixture was slowly warmed from 0 °C to room temperature and stirred for 16 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. Subsequently, the crude product was purified using silica gel column chromatography with an eluent of 5% methanol/dichloromethane (v/v), resulting in the target compound 5-2A (180 mg, 0.87 mmol, 90% yield) as a pale yellow liquid.

IC 50

PEGs

References

[1] Patent: WO2016/154241, 2016, A1. Location in patent: Paragraph 328; 331
[2] Macromolecules, 2004, vol. 37, # 14, p. 5133 - 5135

TETRAETHYLENEGLYCOL MONOMETHYL ETHER(23783-42-8)Related Product Information

• Tetraethylene glycol dimethyl ether
• PENTAFLUOROPHENYL DIPHENYLPHOSPHINATE
• 13-Azido-2,5,8,11-tetraoxa-tridecane
• 2,5,8,11-TETRAOXATRIDECANE-13-THIOL
• m-PEG4-benzaldehyde
• 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate
• 3,6,9,12-tetraoxatridecylamine
• MPEG3-CH2CH2COOH
• m-PEG4-Mal
• MPEG3-NHS
• m-PEG5-Tos
• TETRAETHYLENE GLYCOL DI-P-TOSYLATE
• Tetraethyleneglycol monooctyl ether
• Hexaethylene glycol
• 15-Crown-5
• BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE
• Benzo-15-crown-5
• PENTAETHYLENE GLYCOL