Biotin-PEG3-propionic acid Chemical Properties

Boiling point:

770.7±60.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

solubility 

Soluble in Water, DMSO, DMF

pka

4.28±0.10(Predicted)

form 

Solid

color 

White to off-white

Safety Information

HS Code 

2918999090

Biotin-PEG3-propionic acid Usage And Synthesis

Description

Biotin-PEG3-acid is a biotinylation reagent that can react with amine attached molecule. PEG attached to the biotin gives an extended spacer arm that permits the biotin to reach into the binding pocket of the protein or macromolecule.

Uses

Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

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