Bromo-PEG6-alcohol Chemical Properties

Boiling point:

404.9±40.0 °C(Predicted)

Density 

1.282±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in Water, DCM

pka

14.36±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Bromo-PEG6-alcohol Usage And Synthesis

Description

Bromo-PEG6-alcohol is a PEG linker containing a bromide group and a terminal hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

Uses

Bromo-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromo-PEG6-alcohol(136399-05-8)Related Product Information

• Bromo-PEG3-azide
• Bromo-PEG2-azide
• Bromo-PEG3-t-butyl ester
• Bromo-PEG6-azide
• Bromo-PEG1-Acid
• Bromo-PEG1-azide
• Br-PEG6-bromide
• 3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-
• Bromo-PEG8-t-butyl ester
• Ethanol, 2-[2-(2-bromoethoxy)ethoxy]-
• Bromo-PEG2-acid
• Ethanol, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-
• Ethanol, 2-(2-bromoethoxy)-
• Bromo-PEG5-Azide
• Bromo-PEG6-t-butyl ester
• Bromo-PEG5-t-butyl ester
• Bromo-PEG3-Acid
• Br-PEG3-CH2CO2H