Br-PEG3-CH2CO2H Chemical Properties

Boiling point:

379.7±27.0 °C(Predicted)

Density 

1.446±0.06 g/cm3(Predicted)

pka

3.39±0.10(Predicted)

Br-PEG3-CH2CO2H Usage And Synthesis

Description

Bromo-PEG3-CH2CO2H is a PEG linker containing a bromide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions.

Uses

Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

PEGs

References

[1] Zha Z, et al. Multidentate (18)F-polypegylated styrylpyridines as imaging agents for Aβ plaques in cerebral amyloid angiopathy (CAA). J Med Chem. 2011 Dec 8;54(23):8085-98. DOI:10.1021/jm2009106

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