Bromo-PEG2-t-butyl ester Chemical Properties

Boiling point:

332.0±22.0 °C(Predicted)

Density 

1.240±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Liquid

color 

Colorless to light yellow

InChI

InChI=1S/C11H21BrO4/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h4-9H2,1-3H3

InChIKey

UOYAYHGUAATLSG-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)CCOCCOCCBr

Safety Information

HS Code 

2942000090

Bromo-PEG2-t-butyl ester Usage And Synthesis

Description

Bromo-PEG2-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Bromo-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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