Bromo-PEG5-Azide Chemical Properties

storage temp. 

-20°C, protect from light, stored under nitrogen

form 

Liquid

color 

Colorless to light yellow

Bromo-PEG5-Azide Usage And Synthesis

Description

Bromo-PEG5-azide contain a bromide group and a terminal azide. The bromide (Br) is a very good leaving group for nucleophilic reactions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. PEG5 spacer increases solubility in aqueous media.

Uses

Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Bromo-PEG5-Azide(1402411-90-8)Related Product Information

• Br-PEG6-bromide
• Bromoacetamido-PEG3-t-Butyl Ester
• Bromo-PEG2-phosphonic acid ethyl ester
• Bromo-PEG4-Azide
• Bromo-PEG1-CH2CO2H
• Bromoacetamido-PEG4-t-Butyl Ester
• Ethyl acetate
• Bromo-PEG6-azide
• N3-PEG1-CH2CH2NH2
• Bis(2-azidoethyl)ether
• Bromo-PEG6-t-butyl ester
• Bromo-PEG8-t-butyl ester
• Bromo-PEG5-t-butyl ester
• Bromo-PEG3-Acid
• Br-PEG3-CH2CO2H
• Bromo-PEG1-azide
• 3,6,9,12-Tetraoxatetradecan-1-ol, 14-bromo-
• Bromo-PEG3-t-butyl ester