N3-PEG1-CH2CH2NH2 Chemical Properties

storage temp. 

Amber Vial, Refrigerator, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Oil

color 

Colourless to Off-White

Appearance

yellowish oil

InChI

InChI=1S/C4H11N4O/c5-1-3-9-4-2-7-8-6/h6H,1-5H2/q+1

InChIKey

BJMOEXHRQCURAG-UHFFFAOYSA-N

SMILES

O(C([H])([H])C([H])([H])N=[N+]=N[H])C([H])([H])C([H])([H])N([H])[H]

N3-PEG1-CH2CH2NH2 Usage And Synthesis

Description

Azido-PEG1-amine is a heterobifunctional linker containing an amino(NH2)and an azide (N3) group. The amino group is reactive with carboxylic acids, activated NHS esters,. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Uses

Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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