1-BOC-AMINO-3,6,9-TRIOXAUNDECANYL-11-BROMIDE Chemical Properties

Boiling point:

422.1±35.0 °C(Predicted)

Density 

1.238±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

12.23±0.46(Predicted)

form 

Oil

color 

Yellow

InChI

InChI=1S/C13H26BrNO5/c1-13(2,3)20-12(16)15-5-7-18-9-11-19-10-8-17-6-4-14/h4-11H2,1-3H3,(H,15,16)

InChIKey

GNDQONYTPMGMTM-UHFFFAOYSA-N

SMILES

C(OC(C)(C)C)(=O)NCCOCCOCCOCCBr

1-BOC-AMINO-3,6,9-TRIOXAUNDECANYL-11-BROMIDE Usage And Synthesis

Description

N-Boc-PEG3-bromide is a PEG linker containing a Boc protected amine and a bromide group. The protected amine can be deprotected under mild acidic conditions. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

Chemical Properties

Yellow Oil

Uses

N-Boc-PEG4-bromide is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. N-Boc-PEG4-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC 50

Cleavable Linker; PEGs; Alkyl/ether

References

[1] Jan Anderl, et al. Amatoxin-Conjugates with Improved Linkers. US20130259880A1

1-BOC-AMINO-3,6,9-TRIOXAUNDECANYL-11-BROMIDE(1076199-21-7)Related Product Information

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