HO-PEG24-OH Chemical Properties

Boiling point:

906.6±60.0 °C(Predicted)

Density 

1.117±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

DMSO : 50 mg/mL (46.50 mM; Need ultrasonic)

pka

14.06±0.10(Predicted)

form 

Solid

color 

White to off-white

InChIKey

IEXKUCOGQITOPO-UHFFFAOYSA-N

SMILES

C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

HO-PEG24-OH Usage And Synthesis

Description

PEG25 contains repeating ethylene glycol subunits with two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound under aqueous environments. The water solubility properties of the PEG linker are enhanced with longer PEG chains.

Uses

HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

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